Representation of transverse separation of the inner nuclear layer (INL) endpoint from the outer nuclear layer (ONL) endpoint. The INL of the retina (Red arrows) and the ONL of the retina (Blue arrows) assembled and ended at the BM in the emmetropic eye (A,D). The elongated peripapillary region of the myopes distorts this configuration, which resulted in various endpoints of each layer (E,F).

Contexts in source publication

Context 1

... parameters of the outer retinal layer separation were measured at the center of the optic disc using the same section as above. Advances in OCT enable to discriminate the individual retinal layers with high-resolution noninvasive real-time imaging 19 . In the OCT images, the INL of the retina is defined as a relatively hyporeflective zone, internal to hyperreflective outer plexiform layer 20 . The ONL is defined as the hyporeflective zone between the external limiting membrane and the outer plexiform layer 20 . These individual retinal layers assemble and ends at the BM (Fig. 1D) 21 . However, elongated peripapillary region of myopes distorts this configuration, resulting in various endpoints of each layer (Fig. 1E,F). The endpoint of the ONL was defined as the point where the contin- uous hyporeflective ONL merges at the surface of the BM or sclera. The endpoint of the INL was defined as the point where the continuous hyporeflective INL merges at the surface of BM or RPE. ONL-INL separation was defined as the straight-line distance from ONL endpoint to INL endpoint (Fig. 2). INL-ASCO width was meas- ured as the straight-line distance from INL endpoint to ASCO (Fig. 2). For the sub-analysis, each observer, who was masked with the clinical information of the OCT image, classified each eye into 2 categories with respect to amount of ONL-INL separation: (1) Separated group (ONL-INL separation ? 200 ?m) and (2) Non-separated group (ONL-INL separation <200 ?m). Statistical Analysis. Interobserver reproducibility in measurement of the ONL-INL separation and INL-ASCO width were evaluated by calculating intraclass correlation coefficients 22 . Comparison between 2 groups was performed with the chi-square and Student's t tests. To identify the associated factors with ONL-INL separation, Pearson's correlation analyses were used. P < 0.05 was considered to be statistically ...

Context 2

... parameters of the outer retinal layer separation were measured at the center of the optic disc using the same section as above. Advances in OCT enable to discriminate the individual retinal layers with high-resolution noninvasive real-time imaging 19 . In the OCT images, the INL of the retina is defined as a relatively hyporeflective zone, internal to hyperreflective outer plexiform layer 20 . The ONL is defined as the hyporeflective zone between the external limiting membrane and the outer plexiform layer 20 . These individual retinal layers assemble and ends at the BM (Fig. 1D) 21 . However, elongated peripapillary region of myopes distorts this configuration, resulting in various endpoints of each layer (Fig. 1E,F). The endpoint of the ONL was defined as the point where the contin- uous hyporeflective ONL merges at the surface of the BM or sclera. The endpoint of the INL was defined as the point where the continuous hyporeflective INL merges at the surface of BM or RPE. ONL-INL separation was defined as the straight-line distance from ONL endpoint to INL endpoint (Fig. 2). INL-ASCO width was meas- ured as the straight-line distance from INL endpoint to ASCO (Fig. 2). For the sub-analysis, each observer, who was masked with the clinical information of the OCT image, classified each eye into 2 categories with respect to amount of ONL-INL separation: (1) Separated group (ONL-INL separation ? 200 ?m) and (2) Non-separated group (ONL-INL separation <200 ?m). Statistical Analysis. Interobserver reproducibility in measurement of the ONL-INL separation and INL-ASCO width were evaluated by calculating intraclass correlation coefficients 22 . Comparison between 2 groups was performed with the chi-square and Student's t tests. To identify the associated factors with ONL-INL separation, Pearson's correlation analyses were used. P < 0.05 was considered to be statistically ...