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... mass transfer with respect to square root of the time has been plotted, revealed a linear graph with regression value, stating that the release from the matrix was through diffusion. Further the n value obtained from the Korsmeyer plots i.e. 0.736, 0.756, 0.772 0.785 suggest that the drug release from nanosuspensions was anomalous Non fickian diffusion (Table 6). ...Context 2
... mass transfer with respect to square root of the time has been plotted, revealed a linear graph with regression value, stating that the release from the matrix was through diffusion. Further the n value obtained from the Korsmeyer plots i.e. 0.736, 0.756, 0.772 0.785 suggest that the drug release from nanosuspensions was anomalous Non fickian diffusion (Table 6). ...Similar publications
Este artigo tem como objetivo conduzir uma revisão de literatura que busca ressaltar a importância do Design Centrado no Usuário e Design Empático como guias à usabilidade, Design Universal e Design Inclusivo. Busca-se demonstrar a relevância de tais conceitos através das análises de usabilidade, Design Universal e Design Inclusivo de um produto ta...
Citations
... It infers that out of the four combinations used above, the azithromycin dihydrate (AZI) + Pluronic P-123 is successful for antibacterial behavior. This may be because of the hydrophilic nature of Pluronic P-123 which helps bacterial adsorption of the drug AZI into the micellar core [43,44]. The AZI + L-35 and AZI+L-35 + P-123 did not show significant antibacterial activity. ...
Azithromycin (AZI) has poor aqueous solubility and very low bioavailability. In this study, two nonionic polymeric surfactants, namely Pluronic L-35, and Pluronic P-123, and their binary micelle was used for entrapment of drug AZI. The drug-encapsulated micelles were characterized by UV-spectrophotometry, FTIR, Cloud point, Partition coefficient, and antibacterial studies. We observed improved solubilization of the drug AZI in the binary micellar formulation than in their single micellar systems. The FTIR studies inferred that there is a stable, strong bond formation of the drug AZI with the binary micelle. The partition coefficient values too pointed towards higher solubility of drug AZI in mixed micellar systems as compared to single micellar systems. The free energy of micellization ∆Gomic as determined from the partition coefficient displayed negative values for all three systems indicating spontaneous binding between the drug AZI with the polymeric micellar systems. The highest negative value (-3192.6 kJ/mol) for AZI in the binary system compared to AZI-L-35 (-1620.3 kJ/mol) and AZI-P-123 (-2752.8 kJ/mol) concludes that the drug AZI is better partitioned in the binary micellar system than in the two single micellar solutions. This study can be considered as a potential solubilizing medium for the drug AZI. This is probably the first report of AZI in binary micellar solution.
