Figure 4 - uploaded by Ana María Sánchez Peralta
Content may be subject to copyright.
Source publication
Medical Physics has developed significantly in recent years to be an essential service in the health sciences.
The hospital development in the past two decades has led to the introduction of Electro Medical Service, due to some modifications of the patterns in the diagnostic, analytics, treatments in recovery and in maintaining the patient's healt...
Citations
On the basis of the hypothesis presented in 2005, about insulin, which is considered an important factor in cell differentiation, I consider that people with diabetes mellitus, DM, may have a risk of developing cancer, or undifferentiated growth, having less functional activity of insulin. As this is a differentiating factor deficiency or functional deficit of insulin may involve a smaller brake control of cell cycle progression, which rescues of the cycle allowing differentiation. I will focus on the differentiating insulin regulation rather than regulation of the cell division cycle and mitotic progression, I think it depends on their degree of success compared to cell salvage preventing apoptosis, for its restorative and differentiating activity.
Therefore we seek the relationship between DM and cancer, the prevalence in different types of cancers, the possible common factors and receptor signaling cascade of insulin in their relationship with the cell division cycle.
∞
Basándome en la hipótesis presentada en 2005, respecto a la insulina, que se considera un factor importante de la diferenciación celular, me planteo que las personas que padecen diabetes mellitus, DM, pueden presentar más riesgo de desarrollar cáncer, o crecimiento indiferenciado, al tener menor actividad funcional de la insulina. Al ser ésta un factor de diferenciación su déficit o deficiencia funcional puede implicar un menor control del freno del ciclo celular que rescata de la progresión permitiendo la diferenciación. Me centraré en la regulación diferenciadora de la insulina más que en su regulación del ciclo de división celular y progresión mitótica, que creo que es dependiente de su mayor o menor éxito respecto al rescate celular que evita la apoptosis, por su actividad reparadora y diferenciadora.
Buscaremos por tanto la relación entre la DM y el cáncer, las prevalencias en los distintos tipos de cánceres, los posibles factores comunes y la cascada de señalización del receptor de insulina en su relación con el ciclo y división celular.
