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Turner's syndrome is a disorder in human females characterized by the presence of one normal X chromosome and the complete or partial loss of the second X chromosome. Turner's syndrome is usually diagnosed by karyotyping which is time-consuming, expensive and unfeasible for population screening. The present method of molecular detection was based o...
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Context 1
... digestion a PCR reaction was carried out using a pair of primers specific for the amplification of a part of exon 1 of androgen receptor (AR) gene (accession number GDB: 120556; OMIM entry: 313700) located on the long arm of the X chromosome (region Xq11-q12) ( Fig. 1). PCR was also carried out on normal male and female blood samples after HpaII ...
Context 2
... of Y chromosomal material in Turner females can cause gonadoblastoma so detection of Y chromosomal material is required to prevent the occurrence of gonadoblastoma in shortstature girls. In the present study, Y chromosomal material was not detected because primers used were specific for HUMARA gene located on X chromosomes (Fig. 1), so in this method we can use primers specific for Y chromosome loci to detect Y chromosomal material in 45, XO ...
