Figure 3 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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Receiver operating characteristic (ROC) curve showing the discrimination power of LINC02613. The AUC was 0.925, suggesting an efficient power to discriminate tumors from normal tissues. AUC, area under the curve; TPR, true positive rate; FPR, false positive rate.
Source publication
Background:
The development of transcriptomics has provided a new perspective to understand cancers. However, the role of long non-coding RNAs (lncRNAs) has not been fully elucidated. In the field of breast cancer, exploring the biological role and impact of lncRNAs on patient prognosis is of great importance.
Methods:
Expression data of the lnc...
Contexts in source publication
Context 1
... area under the curve (AUC) was 0.925 (95% CI: 0.908-0.941), representing an efficient power of LINC012613 to discriminate tumors from normal tissues ( Figure 3). ...
Context 2
... GSEA fills this gap. The GSEA results showed that six datasets were significantly enriched in the LINC02613 low expression group, including DNA replication, cell cycle, glycolysis gluconeogenesis, antigen processing and presentation, chemokine signaling pathway and WNT signaling pathway ( Figure S3). Tumor cells are characterized by their unrestricted ability to divide and proliferate; DNA replication and smooth cell cycle are necessary processes for cell proliferation. ...
Citations
... It has been showed that LINC02613 functions as a tumor suppressor in breast cancer by regulating the Wnt signaling pathway. Decreased expression of LINC02613 has been reported to promote cell cycle progression in breast cancer by activating the Wnt signaling pathway via up-regulation of Wnt2 and Wnt3 protein expression (Cui et al. 2022). TINCR is a long non-coding RNA that plays a key role in somatic tissue differentiation. ...
Breast cancer is a complex and heterogeneous disease that poses a significant public health concern worldwide, and it remains a major challenge despite advances in treatment options. One of the main properties of cancer cells is the increased proliferative activity that has lost regulation. Dysregulation of various positive and negative modulators in the cell cycle has been identified as one of the driving factors of breast cancer. In recent years, non-coding RNAs have garnered much attention in the regulation of cell cycle progression, with microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs) being of particular interest. MiRNAs are a class of highly conserved and regulatory small non-coding RNAs that play a crucial role in the modulation of various cellular and biological processes, including cell cycle regulation. CircRNAs are a novel form of non-coding RNAs that are highly stable and capable of modulating gene expression at posttranscriptional and transcriptional levels. LncRNAs have also attracted considerable attention because of their prominent roles in tumor development, including cell cycle progression. Emerging evidence suggests that miRNAs, circRNAs and lncRNAs play important roles in the regulation of cell cycle progression in breast cancer. Herein, we summarized the latest related literatures in breast cancer that emphasize the regulatory roles of miRNAs, circRNAs and lncRNAs in cell cycle progress of breast cancer. Further understanding of the precise roles and mechanisms of non-coding RNAs in breast cancer cell cycle regulation could lead to the development of new diagnostic and therapeutic strategies for breast cancer.
