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ROC curves of three scans and volumes for indicating invasive adenocarcinoma

ROC curves of three scans and volumes for indicating invasive adenocarcinoma

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Background: Invasive pure ground-glass opacity and pre-invasive pure ground-glass opacity have different 5-year overall survival rate and risk of lymph node metastasis and the extent of resection. It is difficult to discriminate these nodules since they share similar CT features and may occur concurrently. The objectives of this study were to inve...

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... ( Fig. 1) in 22 nodules (24.4%), and AIS ( Fig. 1) in 20 nodules (22.3%) ( Table 1). The pre-invasive and invasive groups were comprised of 48 and 42 nodules, respectively. The volumes of preinvasive and invasive pGGO are presented in Table 1. There was significantly difference (P < 0.001) between the two groups. The area under the curve (AUC) (Fig. 2) from ROC was 0.811, and the optimal cut-off value of 814.5 mm 3 for differentiation between pre-invasive and invasive nodules, with a sensitivity of 81.3% and a specificity of 73.8%. In the 30-s scan, 27 out of 42 preinvasive pGGOs (64.3%) had an increased CT value and 40 out of 48 invasive pGGOs (87.5%) had increased CT value, there ...
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... showed increased CT value, excluding nine pre-invasive nodules and seven invasive nodules. The mean CT values of pre-invasive pGGO of one noncontrast enhanced and two contrast-enhanced scans are presented in Table 2. (1) The non-contrast enhanced CT values of pre-invasive and invasive nodules were significantly different (p < 0.001). The AUC (Fig. 2) of noncontrast enhanced scans from ROC was 0.884, and the cut-off values of − 605HU were optimal for differentiation between pre-invasive and invasive nodules, with a sensitivity of 85.4% and a specificity of 83.3%. (2) The contrast-enhanced CT values between groups were significantly different (p < 0.001) ( Table 2). The results of ...
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... using the 60-s scans, which is consistent with Feng Gao's report [21]. He used the same scan-time (60s) and indicated no statistical difference between the presurgical diagnosis based on contrast-enhanced CT images and the pathological diagnosis. In the end, the AUC values in our study obtained from ROC for three scans were 0.884, 0.888 and 0.906 (Fig. 2), respectively. The AUC value of the 30-s or 60-s scan was greater than the non-contrast enhanced scans. The AUC of the 60-s scan was the greatest. Furthermore, logistic regression analysis showed that the CT value of the 60-s scan could be the most significant predicting factor. Ying Zhang et al. using 85-s scan and higher energy (140 ...

Citations

... Among nine studies, five suggested the size of pure GGN as a predictive factor for IA (4,11,12,26,27). Hounsfield unit (HU) was found to be significant in two studies (13,15) and other radiologic characteristics (25), including maximal standard uptake value (SUVmax) (6), were also suggested. ...