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Fe₃O₄-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.
Magnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipita...
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... absence of any diffraction peaks for Fe 3 O 4 is most likely due to the heavy atom effect from gold as a result of the formation of gold- coated Fe 3 O 4 nanoparticles. The diffraction peaks from Fe 3 O 4 provide strong evidence for complete coverage of the magnetic core by gold ( Figure 5). ...
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Sensitive and reliable procedures for detecting vestigial antibiotics are of great relevance for water quality monitoring due to the occurrence of such emergent pollutants in the aquatic environment. As such, we describe here research concerning the use of multifunctional nanomaterials combining magnetic and plasmonic components. These nanomaterial...
Citations
... This pH sensitivity can be utilized for controlled release or targeted delivery applications, where the chitosan-magnet composite responds to changes in pH [38]. ...
... The inclusion of magnetite (Fe₃O₄) in the magnetic chitosan imparts supermagnetic properties to the composite [38,39]. This is beneficial for applications like magnetic separation and targeted drug delivery, where the response to an external magnetic field is critical. ...
... [28,29] They are also widely used as drug carriers in core-shell drug delivery systems, where the metal core is coated with biocompatible materials, which are more important for easier preparation and better control. [30,31] The super magnetic properties of these particles with high saturation magnetism and the possibility of combining with biomolecules provide the targeting of the release of these materials. Due to the prevention of aggregation and also the compatibility of nanoparticles with the human body, the surface of the particles is modified by various factors. ...
Antibiotic resistance is one of the serious challenges that mankind has faced today. According to research, more than 70 % of hospital infections are resistant to at least one antibiotic. Due to the indiscriminate use of antibiotics as well as the genetic changes of bacteria, resistant generations of bacteria have emerged today, which can be very dangerous and lead to the death of the patient, as a result of the need for new drugs are felt and the treatment period and cost increase. Antibacterial nanoparticles can even be used against antibiotic‐resistant bacteria and control them. Green synthesis of magnetite‐copper composite nanoparticles using Alcea can be introduced as a simple, economical, biocompatible, biodegradable and effective method in inhibiting the growth of antibiotic resistant bacteria. These nanoparticles showed a very strong antibacterial effect on antibiotic‐resistant bacteria. It is hoped that with more research and a more detailed examination of the details of these microparticles, they can be used for medical purposes in the not‐so‐distant future. image
... Both hydrogels presented the asymmetric stretching band of C-O-C at approximately 1151 cm −1 [53]. The 1072 and 1029 cm −1 bands are related to C-O bonds in cyclic compounds like glucose [54,55]. Centered at 651 cm −1 an absorption band corresponding to asymmetric Zn-O vibration appeared [56]. ...
Citation: Sánchez-Serrano, S.; González-Méndez, D.J.; Olivas-Valdez, J.A.; Millán-Aguiñaga, N.; Evangelista, V.; Contreras, O.E.; Cardoza-Contreras, M.N. pH-Responsive Chitosan-Doped ZnO Hybrid Hydrogels for the Encapsulation of Bioactive Compounds in Aquaculture. Polymers 2023, 15, 4105. https:// Abstract: In this study, we synthesized and characterized pH-responsive Chitosan-AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. Hydrogel characterization consisted of assessing morphology via SEM, composition via EDS, hydrogels' network components interactions via FT-IR and pH response through swelling behavior determinations. The swelling characterization of the synthesized hydrogels demonstrated a pH-responsive behavior, showing that low pH values caused the hydrogel polymeric network to expand and capture more of the aqueous solution. These characteristics make the synthesized hydrogels suitable for the encapsulation and controlled release of drugs and bioactive compounds in aquaculture. Chitosan_ZnO hybrid hydrogels showed great antimicrobial activity against Vibrio harveyi, even better than that of loaded PB hydrogels. Here, we provide evidence for the potential capacity of Chitosan_ZnO hybrid hydrogels for the preventive and curative treatment of diseases that impact aquaculture animal health and prevent drug resistance by bacteria.
... For example, Salehizadeh et al. developed magnetic core-shell bionanocomposite for bioimaging after synthesizing Fe 3 O 4 -Au nanoparticles (NPs) with stabilizer agent chitosan. Where Fe 3 O 4 displays super magnetic properties by safeguarding magnetic resonance for imaging and optical characteristics exposed by means of Au nanoparticles like the photothermalconverter [140]. Again, AgNPs show hope for photothermal therapy to ablation the unwanted breast carcinoma cells because it acts as a cation marker of the glucose biosensors [141]. ...
The complete dependency on synthetic and artificial materials threatens human life because they adversely affect our ecological system and affect the environment destructively. To mitigate that currently, the most talkative issue is to protect the environment by using biodegradable, nontoxic, biocompatible, and reusable materials for therapeutic, agricultural, food product manufacturing, and packaging purposes. In this case, chitosan-based materials show hopes, as chitosan is the second most plentiful natural biopolymer existing on the planet earth. Moreover, chitosan possesses film-forming abilities, antibacterial behavior, excellent mechanical and thermal properties. At present, chitosan-based bionanocomposite have appeared as ideal candidates for wide-ranging applications owing to the availability for surface modification together with their biodegradable, biocompatible, and nontoxic properties. However, this chapter highlights multiple aspects of chitosan such as its source, structural chemistry, properties, and modification. Additionally, It concentrates on chitosan-based bionanocomposites by describing its preparation techniques, characteristics, and applications. Finally, this chapter discusses the advantages and downsides of chitosan-based bionanocomposite to ensure its application superiority in numerous fields compared to other composites.
... For Ag NPs the pattern clearly shows the main peaks at (2θ) 38.19 0 , 44.37 0 , 64.56 0 , 77.47 0 and 83.44 0 corresponding to the (1 1 1), (2 0 0), (2 2 0), (3 1 1) and (3 3 1) planes, respectively as seen in Fig. 4 (b). By comparing JCPDS (file no: 89-3722), the typical pattern of green-synthesized Ag NPs is found to possess a face-centered cubic (fcc) structure [14]. ...
This work aimed to study the optical absorption and photo-thermal conversion efficiency by the addition of the surfactant (Triton X-100) to Ag/Fe 3 O 4 Nanocomposites (NCs), prepared by using laser ablation technique. The nanoparticles were characterized by several techniques confirming the successfully prepared formation of the elemental composition and the average particle size. The Energy dispersive X-ray spectroscopy techniques (EDX) were helped in evaluating the compositional elemental ratio. The nano crystalline structure and morphology was investigated using X-ray diffraction (XRD) and the transmission electron microscope (TEM). The values of the optical absorption, thermal conductivity and photo-thermal conversion have been reported. A consistent linkage between energy gap (E g), electronegativity (Δχ) and the refractive index (n), depending only on the absorbance spectrum of the samples, which was effectively enhanced with the introduction of Ag Nanoparticles (NPs) to Fe 3 O 4 Nanocomposites. Several relations have been proposed for calculating the refractive index as function of (E g) and (Δχ) values. Moreover, the electronic polarizability (α e), the molar volume (V m), molar refractive index (R m), molar electronic polarizability (α me) was calculated. The photo-thermal conversion results due to the addition of Ag NPs and the (Triton X-100), to Fe 3 O 4 NPs, has been enhanced. The results imply a novel concept, of the effect of Nobel metal "Ag" on the magnetic nanoparticles, optical energy gap, optical conductivity, thermal diffusivity and thermal conductivity. Consequently, we can have an efficient way that can be used as a photo-thermal agent for water desalination.
... The Fourier-transformed infrared (FTIR) spectroscopy analysis of all nanoparticles is shown in Figure 3A. The PLGA shows -C=O, -C-O-C-, and -C-H-characteristic peaks at 1800, 1090, and 3000 cm −1 [30]. The MNP reveals characteristic peaks at 3500 cm −1 (-OH), 1650 cm −1 (-C=O), and 580 cm −1 (Fe-O) [31]. ...
A glioma is the most common malignant primary brain tumor in adults and is categorized according to its growth potential and aggressiveness. Within gliomas, grade 4 glioblastoma remains one of the most lethal malignant solid tumors, with a median survival time less than 18 months. By encapsulating CPT-11 and oleic acid-coated magnetic nanoparticles (OMNPs) in poly(lactic-co-glycolic acid) (PLGA) nanoparticles, we first prepared PLGA@OMNP@CPT-11 nanoparticles in this study. After conjugating cetuximab (CET) with PLGA@OMNP@CPT-11, spherical PLGA@OMNP@CPT-11-CET nanoparticles with 250 nm diameter, 33% drug encapsulation efficiency, and 22% drug loading efficiency were prepared in a single emulsion/evaporation step. The nanoparticles were used for dual-targeted delivery of CPT-11 to U87 primary glioblastoma cells by actively targeting the overexpressed epidermal growth factor receptor on the surface of U87 cells, as well as by magnetic targeting. The physicochemical properties of nanoparticles were characterized in detail. CET-mediated targeting promotes intracellular uptake of nanoparticles by U87 cells, which can release four times more drug at pH 5 than at pH 7.4 to facilitate drug release in endosomes after intracellular uptake. The nanovehicle PLGA@OMNP-CET is cytocompatible and hemocompatible. After loading CPT-11, PLGA@OMNP@CPT-11-CET shows the highest cytotoxicity toward U87 compared with free CPT-11 and PLGA@OMNP@CPT-11 by providing the lowest drug concentration for half-maximal cell death (IC50) and the highest rate of cell apoptosis. In orthotopic brain tumor-bearing nude mice with U87 xenografts, intravenous injection of PLGA@OMNP@ CPT-11-CET followed by guidance with a magnetic field provided the best treatment efficacy with the lowest tumor-associated signal intensity from bioluminescence imaging.
... Salehizadeh and co-workers combined Fe 3 O 4 and gold NPs with a stabilizing substance called CS to create a magnetic core-shell hybrid for bioimaging. With its highly magnetic characteristics, Fe 3 O 4 ensures magnetic resonance imaging (MRI), and gold NPs serve as photo-thermal converters (Salehizadeh, Hekmatian, Sadeghi, & Kennedy, 2012). Modified CS as well as its hybrid materials are currently promising options for bioimaging. ...
The attention to polymer-based biomaterials, for instance, chitosan and its derivatives, as well as the techniques
for using them in numerous scientific domains, is continuously rising. Chitosan is a decomposable naturally
occurring polymeric material that is mostly obtained from seafood waste. Because of its special ecofriendly,
biocompatible, non- toxic nature as well as antimicrobial properties, chitosan-based materials have received a lot
of interest in the field of biomedical applications. The reactivity of chitosan is mainly because of the amino and
hydroxyl groups in its composition, which makes it further fascinating for various uses, including biosensing,
textile finishing, antimicrobial wound dressing, tissue engineering, bioimaging, gene, DNA and drug delivery and
as a coating material for medical implants. This study is an overview of the different types of chitosan-based
materials which now a days have been fabricated by applying different techniques and modifications that
include etherification, esterification, crosslinking, graft copolymerization and o-acetylation etc. for hydroxyl
groups’ processes and acetylation, quaternization, Schiff’s base reaction, and grafting for amino groups’ reactions. Furthermore, this overview summarizes the literature from recent years related to the important applications of chitosan-based materials (i.e., thin films, nanocomposites or nanoparticles, sponges and hydrogels)
in different biomedical applications.
... 's research group[105] has designed a magnetic core-shell nanocomposite for bioimaging, combining Fe 3 O 4 -gold nanoparticles with stabilizing agent chitosan. Fe 3 O 4 showed excellent magnetic properties providing magnetic resonance for imaging. ...
Chitosan is a natural polysaccharide that has demonstrated distinct characteristics for many applications, especially in the biomedical field. This natural polymer offers a variety of properties such as biocompatibility, biodegradability, and non-toxicity, as well as its antibacterial activity and low immunogenicity. Having various active groups, the structure of chitosan may be easily modified by its combination with various nanostructured materials imbibing it with new characteristics that can meet the growing demands of regenerative medicine, to overcome the problems requiring the development of biodegradable and biocompatible nanocomposites. Moreover, chitosan-based nanostructured composites, with improved physical and chemical characteristics, have attracted great attention from researchers in the different biomedical fields such as bone tissue engineering, drug delivery, wound healing, and biosensors, among others. This chapter sheds light on recent research scenario on the different aspects of chitosan-based nanostructured materials, their preparation, their characterization, and their effective utilization in the biomedical area.KeywordsChitosanAntibacterialNanostructured materialsDrug delivery carrierTissue engineeringWound healingBiomedical
... There have been extensive research studies that have applied chitosan coating to gold and magnetic NPs (Abrica-González et al., 2019;Huang and Yang, 2004;Bhumkar et al., 2007;Du et al., 2007). For instance, chitosan has been successfully utilized as coating material for Fe 3 O 4 -coated gold NPs, in order to stabilize optical-magnetic NPs (Salehizadeh et al., 2012). ...
... 13 The self-assembles topology in core/shell amphiphilic chitosan has been used as a target drug delivery in cancer therapy due to its biocompatible and bio-gradable properties. 13,[16][17][18][19] In a previous report, 20 we investigated the optical property of Gd 2 O 3 :Er 3+ nanosphere particles (NSPs) synthesized by the combustion method with EDTA-supported. Gd 2 O 3 :Er 3+ NSPs were also successfully fabricated using the multistep synthesis method. ...
Nanospherical upconversion luminescence particles (UCLPs) Gd₂O₃:Er³⁺ and Gd₂O₃:Er³⁺ @ chitosan (CS) were prepared by step-by-step precipitation and calcination of the available nitrate rare earth sales and chitosan. The morphology and composition of as-prepared samples were characterized by field emission electron spectroscopy and Fourier transform infrared spectroscopy. The synthesized UCLPs were non-agglomerate spheres in uniform nanoscale. The quantitative amount of chitosan was well coated with the gain surface of the UCLPs Gd₂O₃:Er³⁺ to obtain Gd₂O₃:Er³⁺ @CS nanocomposite. The down-conversion luminescent intensity of Gd₂O₃:Er³⁺ NSP is lower than Gd₂O₃:Er³⁺ @CS NSP samples, but luminescent characterizations were non-change. The photoluminescence of the green emission range of all UCLPs samples with chitosan-coated and -uncoated took the leading position. By using a diode laser excitation with 975 nm of wavelength, the detected intensity of red emission is more remarkably detected than green emissions. The two-photon mechanism for both green and red emissions of nanophosphor was observed. As a result, these might be promising opportunities to conjugate with various bio subjects that could be used in medical applications.
