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Quantities encapsulation efficiency

Quantities encapsulation efficiency

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Alginate, a natural biopolymer extracted from brown algae (kelp), has several advantages made it to be used as a matrix for excavation and delivery of a variety of biological agents. The present study was carried out systematically to prepare a new kind of biocompatible and biodegradable nano-particles for loading Bovin Serum Albumin (BSA) and to e...

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Citations

... The retention of a significant amount of water in hydrogel is caused by the presence of hydrophilic groups on the polymeric backbone. The maximum water uptake of an alginate hydrogel depends on many factors, e.g., the cross-linking time or concentration of cross-linker and varies from 50-90% [1], [2], [3]. Unique properties and biological activity make alginate hydrogel widely used in many fields, especially in the biomedical sector. ...
... Alginate hydrogel is also used for encapsulation of cells, genes, proteins, or vaccines. Moreover, soft and flexible structure of alginate hydrogel, likewise similar to extracellular matrix (ECM) gives the potential to the utilization in tissue engineering and regenerative medicine (e.g., scaffold) [2], [4]. ...
Chapter
The application of additive manufacturing (AM) technology in biomedicine offers many advantages due to the possibility of personalization and precision in shape accurate reproduction or dose of drug selection. AM technique enables the use of a wide variety of biocompatible materials, which can be applied even in the form of hydrogel. However, the use of sodium alginate as a bioink is encountered with some difficulties, for example, problem with shape retention during fabrication before being cross-linked. In this paper, methods used in extrusion-based method that contributes to maintaining the precision and quality of the print by reducing the spill ability of alginate hydrogel are described. This paper presents one of the methods, which supports the alginate hydrogel manufacturing process—freeform reversible embedding of suspended hydrogels (FRESH), as well as the optimization of the manufacturing process parameters to improve the quality of prints.KeywordsAdditive manufacturingBioprintingSodium alginateHydrogel bioinkManufacturing parametersFRESH method
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