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The Helicobacter pylori is a Gram-negative, microaerophilic bacterium found usually in the stomach and use a number of mechanisms to survive in the stomach lumen. The presence of these bacteria in the stomach can lead to gastritis and reduction in stomach acid production. Acute inflammation can directly damage to the peripheral cells that are respo...
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Background: Infection with Helicobacter pylori ( H. pylori ) can cause chronic gastritis and other digestive tract diseases, and represents a public health concern. Current anti- H. pylori treatment can result in antibiotic resistance and other adverse reactions. Huangqi Jianzhong decoction (HQJZD) is a prescription form of traditional Chinese medi...
Background
Helicobacter pylori infection is a well-recognized cause of gastric diseases, including chronic gastritis, peptic ulcer, and gastric cancer. Vacuolating cytotoxin-A (VacA) and cytotoxin-associated gene A protein (CagA) play a role in the pathogenesis of H. pylori-related gastric diseases. Also, extragastric disorders are frequent morbid...
Background
Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4-secretion system (T4SS) and the cytotoxin CagA. Translocation of CagA through the T4SS triggers host-signaling pathways. One of the T...
Helicobacter pylori is a Gram-negative bacterium that causes chronic atrophic gastritis and peptic ulcers and it has been associated with the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT). One of the more remarkable characteristics of H. pylori is its ability to survive in the hostile environment of the stomach....
2016): Lack of association between gastric cancer and HOPQ alleles in Helicobacter pylori.-Genetika, Vol 48, No.3, 893-902. Helicobacter pylori use a number of mechanisms to survive in the stomach lumen. The presence of these bacteria in the stomach can lead to gastritis and reduction in stomach acid production. Acute inflammation can directly dama...
Citations
... Therefore, the inflammatory response generated by the body is relatively weak, thus reducing the immune suppression response of the body and reducing the occurrence of complications [21,22]. In addition, our study indicated that the incidence of postoperative complications in the OG presented reduction relative to the CG, while the GLQI scores of the OG presented significantly higher than that of the CG at discharge, implying that laparoscopic radical gastrectomy could decrease the incidence of postoperative complications along with promote the quality of life of GC patients, which was in line with previous studies [23][24][25][26][27]. ...
... To further confirm the relationship between CST1 and GC, we first analyzed CST1 expression through online databases. The results showed up-regulated CST1 in most tumors and GC, which was consistent with our experimental results and previous studies [26][27][28][29][30][31]. In the prognosis analysis, a connection between CST1 expression and the prognosis and survival of GC patients was identified in the Kaplan-Meier Plotter database but not in GEPIA and ENCORI databases, which may be caused by the inconsistency of information recorded in the three databases. ...
... As a targeted anti-angiogenesis drug, anlotinib can compared to docetaxel [23]. Additionally, Si et al. have proposed that anlotinib can enhance the quality of life compared to placebo in advanced NSCLC patients who have accepted more than two chemotherapy treatments [24][25][26][27]. ...
... The study revealed that miR-96 expression was normal in healthy tissues but abnormal in cancerous tissues, and the abnormal expression levels could differentiate between different CTC states. Kong et al. [26] and others [27][28][29][30] reported a significant up-regulation of the miR-183 family in gastric cancer tissues. However, Li et al. [31] reported that miR-182 acts as an oncogenic factor in gastric adenocarcinomas and is down-regulated through the downregulation of CREB1 (cyclic adenosine monophosphate-responsive element binding protein). ...
... There are many genetic, biochemical, physiological, and epigenetic findings relevant to Gastric Cancer. [15][16][17][18][19][20]. ...
... By silencing FZD7 expression, it is possible to significantly inhibit the invasion and migration of gastric carcinoma cells (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Data show that miRNA can pair with the 3'-UTR region of the target gene to form a silent complex, thereby promoting or suppressing cancer (25)(26)(27)(28). Geng et al. (29) found that miR-NA (such as miR-27b) can negatively regulate FZD7, thereby affecting Helicobacter pylori-induced gastric tumorigenesis and inhibiting the proliferation of gastric tumor cells. ...
... Although the expression level of miR-145-5p in cancer tissues and serum of patients with non-small cell lung cancer is controversial (36). This genetic phenomenon may also occur in other cancers (37)(38)(39)(40). This study showed that the expression level of miR-145-5p was significantly reduced in NSCLC, which may regulate the development of NSCLC by targeting oncogenes such as EGFR and MYC. ...
... The main components of Miswak are sulphur, alkaloids, and butanediamide which have antibacterial activity, chlorides and fluorides help in enamel remineralization and others (15). Examining gene expression in bacteria and its effects on the host has already been reported a lot (15)(16)(17)(18). The analysis of the previous reports supports the anti-cariogenic properties of polyphenols on cariogenic Streptococci, probably due to a direct effect of polyphenols against S. mutans; an interaction of polyphenols with microbial membrane proteins inhibiting the adherence of bacterial cells to the tooth surface; and the inhibition of glucosyl transferase and amylase in bacteria. ...
Dental caries is a multifactorial infectious chronic disease caused by particular bacteria and their virulence products that causes demineralization and progressive deterioration of the dental enamel. Many studies have proven miswak to have a critical antibacterial impact, particularly on cariogenic bacteria and periodontal pathogens, in the oral cavity. This study aimed to investigate the effect of different concentrations of Salvadora persica plant extract on growth and virulence gene expressions at mRNA levels in S. mutans. A total of 191 clinical samples from tooth swabs were collected, and sub-cultured on specific medium agar identified using biochemical and molecular approaches. MIC for the extract was determined and a bacterial growth curve was made to determine the growth phases and the optimum time for adding the extract at different concentrations. RT-qPCR technique was performed, and the REST-2009 software program was used for data analysis. Out of 191 swabs from the tooth 31 isolates were identified using several biochemical and molecular tests. Several S. mutans biofilm-related virulence genes and their Ct values were produced from RT-PCR under the effect of low and high doses of Meswak concentrations. Ct values and reaction efficiency were produced in RT-qPCR by Rotorgen3000, data then were analysed by REST-2009 software. Five isolates were selected to examine the effect of the extract on the mRNA levels using qPCR after growing them with both doses of the extract for about 30hrs. Levels of virulence gene mRNA were regulated differentially in cultures with added both extract doses. The isolates produced significantly lower virulence gene mRNA levels in cultures grown with both plant extract doses. The results produced in this study here provide new insights regarding several virulence gene expressions in S. mutans at the molecular levels when grown under different concentrations of Salvadora persica plant extract.
... Etomidate is an intravenous sedative drug that can calm and hypnotize patients and make them forget and after continuous infusion, there are no massive residues in the patients. Studies have revealed that (20)(21)(22)(23)(24)(25), the application of etomidate combined with propofol anesthesia has few effects on cognitive dysfunction in patients undergoing gastric cancer surgery, with a low incidence rate of postoperative adverse reactions, and this study confirms these findings. ...
This study examined how etomidate combined with propofol affected cognitive function, inflammation, and immunity in patients undergoing gastric cancer surgery. 182 gastric cancer patients treated in our hospital were enrolled and randomly divided into two groups, namely group A (anesthetized using etomidate) and group B (anesthetized using etomidate combined with propofol). Then the cognitive function, inflammation and immunity indicators were determined in the two groups. Compared with group A, group B exhibited shorter operation duration and hospital stay and smaller bleeding volume (p<0.01). At 3 d after the operation, group B had a higher Ramsay score, but a lower visual analogue scale (VAS) score than group A (p<0.05). Moreover, the mini-mental state examination (MMSE) score was lower in group A than that in group B (p<0.01). At the end of the operation, the heart rate (HR), mean arterial pressure (MAP) and saturation of pulse oxygen (SpO2) were decreased to a great extent in both groups compared with those before anesthesia (p<0.05). Compared with those before anesthesia, the levels of immunoglobulin (Ig)M, IgG and IgA were lower in group A at the end of the operation and 1 and 3 d after the operation (p<0.05), but they were substantially higher in group B than those in group A (p<0.05). At the end of the operation and 1 and 3 d after the operation, the levels of the T-cell subset indicators decreases in group A were greater than those in group B (p<0.05). Etomidate combined with propofol has few influences on the immune and cognitive functions of gastric cancer patients and can effectively lower the expression levels of inflammatory factors in these patients.
... This indicates that Dex is relatively safe and well tolerated by patients, and its adverse reactions like nausea and vomiting, hypotension, hypertension, respiratory depression, and bradycardia will disappear with drug metabolism over time. There are already many reports of factors affecting the occurrence of gastric cancer (21)(22)(23)(24)(25)(26)(27). ...
This study was performed to analyze the application of dexmedetomidine (Dex) in anesthesia for gastric cancer surgery and its effect on serum inflammatory factors in patients. In this regard, a total of 78 patients with gastric cancer who were hospitalized in our hospital from January 2020 to September 2023 and received general intravenous anesthesia were randomly divided into two groups (n=39 in each group). The conventional group was given the same volume of 0.9% sodium chloride solution 10min before induction of anesthesia, and the Dex group was given Dex1μg/kg intravenous pump 10min before induction of anesthesia. The hemodynamics, serum levels of IL-1β, IL-6, TNF-α, CRP, propofol, remifentanil, and the total incidence of adverse reactions were compared between the two groups at different periods. The results showed that the mean arterial pressure (MAP), heart rate (HR), serum IL-1β, IL-6, TNF-α and CRP in the Dex group were compared with those in the routine group (P>0.05). MAP and HR in T1, T2 and T3Dex groups were lower than those in the conventional group (P<0.05). The serum levels of IL-1β, IL-6, TNF-α and CRP in T4 and T5 of the Dex group were lower than those of the routine group (P<0.05). The dosage of propofol and remifentanil in the Dex group was lower than those in the conventional group (P<0.05). The total incidence of adverse reactions in the Dex group (5.13%) was compared with that in the conventional group (10.26%), P>0.05. It was concluded that Dex can effectively maintain the stability of hemodynamics during gastric cancer surgery, reduce the dosage of propofol and other anesthetic drugs, reduce inflammation, and has a certain safety without obvious adverse reactions.
