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Context in source publication
Context 1
... lesions were intermittently pruritic and nontender. Finger and periungual examinations revealed proximal nailfold erythema, periungual telangiectasias, and dilated capillary loops with dropout (Fig 2). A comprehensive skin exam was negative for heliotrope rash, shawl or V-neck erythema, Gottron papule/sign, and calcinosis. ...
Citations
... Some studies have associated the NXP-2 phenotype with a lack of skin findings or nonspecific skin rashes that stray from typical DM findings. [9][10][11] F I G U R E 2 CT scan of the chest (A) before treatment and (B) after 5 months of treatment with improvement on prednisone taper and mycophenolate mofetil. The diagnosis of amyopathic DM can also be challenging due to overlapping features with conditions such as cutaneous lupus erythematosus. ...
Key Clinical Message
Nuclear matrix protein (NXP‐2) positive amyopathic dermatomyositis (DM) may present without classic symptoms like muscle weakness, dysphagia, and edema, and mimic conditions like cutaneous lupus. Given DM's association with malignancy and interstitial lung disease, prompt and accurate diagnosis is important. Testing for myositis‐specific antibodies aids diagnosis in ambiguous cases.
