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Proposed mechanism for androstenedione from testosterone and epitestosterone by P450 enzymes through a gem-diol and dual HAT pathways adapted from [12]

Proposed mechanism for androstenedione from testosterone and epitestosterone by P450 enzymes through a gem-diol and dual HAT pathways adapted from [12]

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Over the last 50 years, advances in the production of stable isotopes and mass spectrometry instrumentation have fueled elucidation of endogenous biochemical pathways and underpinned quantitative methodology in analytical chemistry, to name but two areas impacted. The topic covering the use of stable isotopes in pharmacological research is very bro...