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Background: Acute hypoxemic respiratory failure (AHRF) is common in COVID-19. Tracheal intubation in such patients is fraught with higher mortality, therefore, high flow nasal oxygen therapy (HFNOT) is being used in AHRF. In this study, we aimed to determine the impact of HFNOT on oxygenation status and also various predictors of HFNOT failure. Met...
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Context 1
... and higher values of IL-6, D dimer and random blood sugar levels (Table 1). On univariate analysis, age>65 years, APACHE II>20 and SOFA>7, 2-hour ROX, 6-hour ROX index, Baseline P/F ratio, SpO2<70%, D-dimer>2 mg/L, IL-6>40 pg/mL and RBS>250 mg/dL, absence of prone positioning were statistically significant factors (Odds ratio>1, p<0.05) contributing to the HFNOT failure (Table 4). After incorporating all these factors related to HFNOT failure into multivariate logistic regression analysis, we found that age>65 years, SOFA>7, APACHE II>20, admission P/F ratio<100, SpO2<70%, HR>120 bpm, D-dimer>2mg/L, IL-6>40 pg/mL, RBS>250 mg/dL, 6-hour ROX Index<3.5, 1-hour ROX Index<3, were independent prognostic factors of HFNOT failure. ...Context 2
... on ROC analysis, we found, highest AUROCs with, APACHE II, SOFA score, D dimer, ROX index at 6-hour,1 hour, IL-6 and RBS. Among these indicators, the APACHE-II greater than 20 was the most relevant predictor of HFNOT failure (Table 4, Figure 4). ...Context 3
... and higher values of IL-6, D dimer and random blood sugar levels (Table 1). On univariate analysis, age>65 years, APACHE II>20 and SOFA>7, 2-hour ROX, 6-hour ROX index, Baseline P/F ratio, SpO2<70%, D-dimer>2 mg/L, IL-6>40 pg/mL and RBS>250 mg/dL, absence of prone positioning were statistically significant factors (Odds ratio>1, p<0.05) contributing to the HFNOT failure (Table 4). After incorporating all these factors related to HFNOT failure into multivariate logistic regression analysis, we found that age>65 years, SOFA>7, APACHE II>20, admission P/F ratio<100, SpO2<70%, HR>120 bpm, D-dimer>2mg/L, IL-6>40 pg/mL, RBS>250 mg/dL, 6-hour ROX Index<3.5, 1-hour ROX Index<3, were independent prognostic factors of HFNOT failure. ...