Figure - available from: Journal of Pharmacokinetics and Pharmacodynamics
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Population PKPD model structure for efmarodocokin alfa. CL clearance, Cp serum efmarodocokin alfa concentration, Emax maximum effect, EC50 concentration to achieve 50% of maximum effect, Kin synthesis rate, Kout degradation rate, PK pharmacokinetics, PD pharmacodynamics, Q2 inter-compartment clearance between central compartment and peripheral compartment 1, Q3 inter-compartment clearance between central compartment and peripheral compartment 2, Vc volume of distribution in central compartment, Vp1 volume of distribution in peripheral compartment 1, Vp2 volume of distribution in peripheral compartment 2
Source publication
Efmarodocokin alfa (IL-22Fc) is a fusion protein of human IL-22 linked to the crystallizable fragment (Fc) of human IgG4. It has been tested in multiple indications including inflammatory bowel disease (IBD). The purposes of the present analyses were to describe the population pharmacokinetics (PK) of efmarodocokin alfa and perform pharmacodynamic...
