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Besides lesions considered to be premalignant (such as erythroplasia, Bowen disease), a number of other potentially malignant lesions with higher or lower degree of epithelial dysplasia depending on the keratinization degree or determined by the action of carcinogens and irritants substances are described in the oral mucosa. Although they are pract...
Context in source publication
Context 1
... microscopic structure of the tumor on serial sections from different parts of it was characterized by a marked lesional pleomorphism. It was formed made up of both epithelial cell proliferations and mesenchymal tissue ( Figure 6). The epithelial component was composed of cells with highly variable morphology: cubic, cylindrical, spindle-like, plasmacytoid; the transition from one cell type to another was brutal. ...
Citations
... Dental factors associated with CMI include mal-positioned, sharp/fractures/rough surfaces of natural teeth. Functional factors associated with CMI include parafunctional habits such as cheek biting, and tongue thrusting [14][15][16][17][18]. Mucosal pathologies due to CMI are related to its intensity and duration which range from frictional keratosis in mild conditions to fibrous hyperplasias in moderate to severe conditions [19][20][21]. Considering the high morbidity and mortality rates of OSCC, strategies to prevent the disease is the need of the hour. Carcinomas associated with tobacco-related habits can be prevented by counseling and de-addiction programs, however the other risk factors such as microbes, chronic trauma can be prevented by routine dental examination and adequate prophylactic measures. ...
The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma. PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations ‘chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; chronic trauma and oral cancer.’ Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for oral squamous cell carcinoma. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-oral squamous cell carcinoma. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p<0.00001) between the chronic oral mucosal irritation and oral squamous cell carcinoma with an overall risk ratio of 2.56 at a confidence interval of 1.96 to 3.35. Chronic oral mucosa irritation has a significant association with oral squamous cell carcinoma, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.
... The systematic review carried out has indeed led to select only four articles. Some authors describe the only clinical features [1], others present the pathological analysis [2][3][4]. One of them was able to describe the clinical and a partial picture of the anatomopathological features [5]. ...
... Following the selection of studies according to the inclusion and exclusion criteria and the removal of duplicate articles, full versions of 15 articles were selected for reading ( Figure 1). After reading, 4 studies [2][3][4][5] met the inclusion criteria and were selected for the final analysis. Thus, 10 studies were excluded [7][8][9][10][11][12][13][14][15]; the reasons for exclusion are specified in Figure 1. ...
... The typical appearance is a non-viral papilloma which is developing at the expense of filiform papillae. It is likely a traumatic origin [2]. ...
