Figure 8 - uploaded by Hassan Kassassir
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Platelet flow and adhesion in mesentery veins of healthy and diabetic mice. Anesthetized mice were injected with either DyLight488‐conjugated anti‐GPIbβ antibodies and placed on a stage of an upright microscope equipped with saline immersion objectives. Platelets flowing in the blood and those attached to the wall of a mesentery vein were evaluated in saline‐injected (control) (A) and STZ‐injected (diabetic) (B) mice.
Source publication
Increasing number of transgenic and knockout strains of laboratory rodents has been developed to provide reliable models of human cardiovascular diseases. Due to apparent differences in platelet physiology, morphology, biochemistry, etc. between rodents and men, methods employed to study blood platelets in rodents should always consider these diffe...
Citations
The present review was provoked by the demand of a comprehensive overview on the recent scientific achievements revealing new horizons for advanced applications of organic dyes in service of contemporary medicinal chemistry, pharmacy and biomedicine. The review outlines the basic structural characteristics, physicochemical properties and biological activity of various dye families and suggests modified classifications of dyes according to their structural moieties and bioorganic functionalities serving the necessities of modern analytical chemistry and biochemistry. A major part of the review focuses on the pros and cons of the use of dyes as vectors in bioanalytic assays. The latter is based on comparative analyses of the limitations of some widely applied classical methodologies vs. the advantages and outcomes of the application of newly-designed dye molecules in modern dye-based bioassay techniques.
