Fig 3 - uploaded by Nagwa El-Nefiawy
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Photomicrographs of sections in the thoracic aortae of adult rats (immune staining with anti-alpha smooth muscle actin antibody, ×400). (A) Group I (adult control): notice homogenous packed layers of strong positive alpha actin filaments of smooth muscle fibers (arrows) in tunica media located between elastic laminae. (B) Group II (adult rats treated with ciprofloxacin): weak positive immune reaction for alpha smooth muscle actin is observed (asterisks).
Source publication
In this study, the effect of oral ciprofloxacin on the structure of the thoracic aorta in rats was investigated. Twenty four male albino rats were divided into 4 groups (6 rats/group): group I (adult control), group II (adult rats treated with ciprofloxacin), group III (senile control), and group IV (senile rats treated with ciprofloxacin). Rats in...
Contexts in source publication
Context 1
... staining for the adult control group (group I) showed homogenous packed layers of dense alpha actin positive SMCs located between elastic and collagen fibers lamellae (Fig. ...
Context 2
... group II, weak positive immune reaction for alpha smooth muscle actin was observed involving wide areas of the muscle bulk of the tunica media (Fig. 3B). ...
Context 3
... staining for the adult control group (group I) showed homogenous packed layers of dense alpha actin positive SMCs located between elastic and collagen fibers lamellae (Fig. ...
Citations
Aortic aneurysm (AA) and aortic dissection (AD) are prevalent severe cardiovascular diseases that result in catastrophic complications and unexpected deaths. Owing to the lack of clinically established and effective medications, the only treatment options are open surgical repair or endovascular therapy. Most researchers have focused on the development of innovative medications or therapeutic targets to slow the progression of AA/AD or lower the risk of malignant consequences. Recent studies have shown that the use of fluoroquinolones (FQs) may increase susceptibility to AA/AD to some extent, especially in patients with aortic dilatation and those at a high risk of AD. Therefore, it is crucial for doctors, particularly those in cardiovascular specialties, to recognize the dangers of FQs and adopt alternatives. In the present review, the main clinical observational studies on the correlation between FQs and AA/AD in recent years are summarized, with an emphasis on the relative physiopathological mechanism incorporating destruction of the extracellular matrix (ECM), phenotypic transformation of vascular smooth muscle cells, and local inflammation. Although additional data are required, it is anticipated that the rational use of FQs will become the standard of care for the treatment of aortic diseases.
