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Photomicrograph of fetal skin from treated group shows significant thickening of epidermis (E) with large intercellular spaces. Dermis (D) shows hair follicles comprising a few premature buds (blue arrow and red arrow). H and E stain X 400. 

Photomicrograph of fetal skin from treated group shows significant thickening of epidermis (E) with large intercellular spaces. Dermis (D) shows hair follicles comprising a few premature buds (blue arrow and red arrow). H and E stain X 400. 

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Introduction: For differentiation and maintenance of epithelial cells in vitro and vivo under the influ-ence of retinoic acid treatment, skin seems to be a major target organ for both the normal and patholo-gical states. The current study was conducted to evaluate the effects of retinoic acid on fetal skin if given to albino mice during pregnancy....

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... there appeared to be gaps between Biomedica Vol. 30, Issue 1, Jan. -Mar., 2014 the cells which were presumably due to accumulat- ion of inter cellular matrix. Epidermis was discer- nibly thicker than that of the control group; this was possibly due to an increase in the number of cells resulting from rapid proliferation of those in stratum basal (Fig. 2). There was no change in der- mal connective tissue of the skin of both groups. Mean epidermis thickness of treated group was hi- gher when compared to that of the control groups, the difference was statistically significant (p-value < ...