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Photograph of appearance of adherence (arrow) between wound edges and the healing of the full-thickness umbilical wound on the end of experiment at day 15 in one of the Therankeron treated animal.

Photograph of appearance of adherence (arrow) between wound edges and the healing of the full-thickness umbilical wound on the end of experiment at day 15 in one of the Therankeron treated animal.

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The proper, swift and better healing process is the always goal of any tissue repair, although its accomplishment is not an easy task. Many theories and strategies have been suggested to improve healing process and achieve the perfect tissue healing. Our hypothesis implies that using of Therankeron could enhance and accelerate wound healing process...

Contexts in source publication

Context 1
... clinical observations showed relatively more better healing process of Therankeron skin wounds in the term of shortage of time for adhesion between the wound edges ( Fig. 3) and less scar tissue formation at wound edges as compared to normal saline control group throughout the 15 days of ...
Context 2
... clinical observations showed relatively more better healing process of Therankeron skin wounds in the term of shortage of time for adhesion between the wound edges ( Figure 3) and less scar tissue formation at wound edges as compared to normal saline control group throughout the 15 days of experiment. ...
Context 3
... clinical observations showed relatively more better healing process of Therankeron skin wounds in the term of shortage of time for adhesion between the wound edges ( Figure 3) and less scar tissue formation at wound edges as compared to normal saline control group throughout the 15 days of experiment. ...

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Citations

... The dogs were fasted from food for 24 hours prior to surgery. under general anesthesia protocol, the surgical operations were performed by administering atropine sulphate 1% as a premedication at a dose of 0.04 mg /Kg B.W [18] after 10 minutes a mixture of xylazine 2% (VMD-Belgium) and ketamine 10% (Alfasan-Holland) were administered intramuscularly at doses of 10 mg/kg and 2 mg/kg of body weight, respectively [19]. The back of the animal was prepared according to ideal aseptic techniques; A 5 cm longitudinal full thickness incision was made. ...
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LATELET RICH FIBRIN (PRF) is a biological and innovative therapeutic which has important role in regenerative injured tissue. The aims of this study were to prepare lyophilized-PRF and determine its applications during wound healing, depending on histopathological and immunohistochemistry parameters. Six healthy, adult local breed dogs were used, the animals were randomly divided into 2 experimental main groups (treated and control) 6 animals for each group, ten ml of whole blood was aspirated from the same animal for platelet rich fibrin preparation and centrifugation of this fresh blood at 3000 rpm for 10 minutes was performed, the resulted PRF layer was removed to prepare lyophilized PRF by freezing and was stored at −80C∘ then the sample was freeze-dried for 12 hours by using Labconco lyophilizer at −51C∘ Surgical full thickness incision wound of 5cm length was performed under general anesthesia on back of dogs under aseptic technique, treated group Lyophilized A-PRF (Right side) was applied subcutaneously while normal saline 0.9% was applied instead of Lyophilized A-PRF in the control group (Left side). The wound was closed using surgical silk suture. The histological criteria for wound healing, inflammatory cell infiltration, re-epithelialization, and granulation tissue formation were evaluated according to the scoring system (0-4), Furthermore, the results of quantitative analysis of immunohistochemistry of PDGF expression showed that the group treated with Lyph-PRF was moderate, intense and mild cytoplasmic staining reactivity on the first, third and seventh days respectively after PO compared to the control.