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Pharmacological properties and molecular formula of Ranunculus species compounds reported in articles published from 2010 to 2021.
Source publication
The genus Ranunculus includes approximately 600 species and is distributed worldwide. To date, several researchers have investigated the chemical and biological activities of Ranunculus species, and my research team has found them to have antimalarial effects. This review is based on the available information on the traditional uses and pharmacolog...
Context in source publication
Context 1
... many other species related to Ranunculus have also been studied to evaluate their pharmacological activities, the novel bioactive compounds found in Ranunculus species with high pharmacological effects show nutraceutical and pharmaceutical potential. Pharmacological properties and molecular formula of Ranunculus species compounds reported in articles published from 2010 to 2021 are summarized in Table 1. [48] 5. Pharmacological Activities of Ranunculus Species 5.1. ...Citations
... Identi cation of Potential Bioactive Compounds and Targets of RTE 29 active components from the RTE were searched in published literatures [15,[20][21][22][23][24][25][26][27] (Table S1). After eliminating the overlapping proteins, 461 associated proteins were obtained for subsequent analysis. ...
Purpose
This study was conducted to assess the pharmacological mechanisms of ethyl acetate extract of Ranunculus ternatus Thunb. (RTE) in combating esophageal squamous cell carcinoma (ESCC) through the integration of network pharmacology analysis and experimental validation.
Methods
Utilizing network pharmacology methodologies, potential targets of RTE and targets associated with ESCC were identified from public databases. Subsequently, protein-protein interaction (PPI) network analysis, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted to ascertain the key targets and pathways through which RTE may exert its effects against ESCC. Finally, the putative mechanisms of action of RTE on ESCC, as predicted by network pharmacology analysis, were validated through in vitro experiments.
Results
A total of 274 potential targets were retrieved by searching the intersection of RTE and ESCC targets. 14 key genes of RTE acting on ESCC were obtained combined Component-Target-Disease Pathway and PPI network analysis, including AKT1, HSP90AA1, EGFR, MAPK1, and TNF.GO biological process analysis mainly involved in regulation of inflammatory response, response to lipopolysaccharide, and regulation of apoptotic signaling pathway, etc. KEGG signaling pathway analysis mainly related to MAPK signaling pathway, Relaxin signaling pathway, and PI3K/Akt pathway, etc. Then, the results of in vitro experiment indicated that RTE could inhibit proliferation of EC-109 and TE-13 cells. The in vitro experiments validated that RTE exhibited its therapeutic effects on ESCC mainly though the regulation of cell proliferation via MAPK/ERK and PI3K/Akt signaling pathways.
Conclusion
This study demonstrated that it may offer a useful tool to clear the molecular mechanism of RTE on ESCC by combination of network pharmacology prediction with experimental validation.
... Ranunculus species have been used in ethnomedicine to affect various medical conditions, such as skin diseases, hemorrhoid, wound healing, rheumatism, nebula, malaria, tuberculosis, jaundice, edema, abscess, pain, constipation, asthma, gout, cancer, and hypertension (Aslam et al., 2012). Pharmacological studies described anti-inflammatory, antiviral, antihypertensive, hepatoprotective, antimalarial, antioxidant, anticarcinogenic, analgesic, antibacterial, antifungal and cytotoxic activities of Ranunculus species (Goo, 2022). Methanolic extract of whole Ranunculus japonicus could be used in treatment of antirheumatoid arthritis because it Inhibits migration capacity of rheumatoid arthritis fibroblast-like synoviocytes (Wang et al., 2021). ...
... The fresh R. sceleratus of whole plant exerted hepatoprotective ability (Zhang et al., 2020). Phytochemical screening on Ranunculus species proved presence of flavonoids, lactone glycosides, saponins, alkaloids, tannins, phenols, cardiac glycosides, anthocyanins, carbohydrates, coumarins, and phytosterols, esters, fatty acids, organic acids and amino acids (Goo, 2022). The data on biological properties of R. constantinapolitanus DC are limited in the literature. ...
... Antibacterial and antiprotozoal effects, immunomodulatory and anticarcinogenic properties, and the anti-inflammatory and analgesic actions of Ranunculus spp. plants used in traditional medicine applications have been confirmed [2]. Galphimia spp. is an important medicinal plant in Mexico, which has many applications in traditional medicine. ...
... Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities. Jacaranone (2) showed the highest antiproliferative activity against MDA-MB-231 (human breast cancer) and C33A (human cervical cancer) cells. The volatile compounds of eight peach varieties grown in Bulgaria (Prunus persica L.), including "Filina", "Gergana", "Ufo-4", "July lady", "Laskava", "Flat Queen", "Evmolpiya", and "Morsiani 90", were analyzed for the first time [12]. ...
Plant bioactive compounds are essential for human health due to their multiple biological effects, such as antioxidant, anticarcinogenic, antiallergenic, anti-inflammatory, antimutagenic, and antimicrobial activities, which can have beneficial effects on various noncommunicable diseases, such as autoimmune, inflammatory, cardiovascular, cancer, metabolic, and neurodegenerative diseases [...]
Ranunculus plant species, one of the endemic plants, are used in the treatment of various diseases such as febrile diseases, rheumatism and inflammatory rashes due to their pharmacological and toxicological activities. Considering these features, it was aimed to investigate the cytotoxic effects of Ranunculus poluninii on cancer cell lines, bacteria and yeasts. For this purpose, the extract of the plant was obtained by methanol extraction. Different concentrations of stock were prepared from this plant and applied to A549 and HCT116 cancer cell lines, and MTT assay was performed to determine cell viability. In addition, MIC values were determined by applying the prepared plant extract to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, Candida albicans and Candida glabrata. Our results showed that Ranunculus poluninii was reduced cell viability to 83.7% at 100 µg/mL and 79% at 200 µg/mL on A549 and HCT116 respectively. In addition, it decreased both Candida albicans and Candida glabrata growth to 91.5% at 800 µg/m and 95.1% at 50 µg/mL respectively. Our results suggest that Ranunculus poluninii has anticancer effect and antifungal activity.
There is limited knowledge regarding the efficacy of the use of herbal extracts in orofacial pain. A systematic review and a meta-analysis of randomized controlled trials, to assess the analgesic effect of herbal extracts on pain intensity in various painful orofacial conditions was conducted. Sixty-two studies were included. The intervention treatment consisted in the use of herbal extracts compared with placebo and/or standard treatment. The primary outcome was pain intensity assessed before and after the intervention, using any pain scale from 0 to 10. Pain scores were compared with baseline scores in each treatment. When compared with standard therapy, the pooled results of the patients who received herbal extracts reported lower pain intensity; in periodontal pain (mean difference [MD] = -0.92, 95% confidence interval [-6.69, 4.85]), oral surgery pain (MD = 18.80 [8.80, 28.79]), oral neuropathic pain (MD = 20.34 [6.16, 34.52]), endodontic pain (MD = -8.04 [-11.72, -4.37]), oral mucosal pain (MD = 8.74 [2.76, 14.73]), and temporomandibular pain (MD = 30.94 [6.04, 55.83]). The findings indicate a pain-attenuating effect of herbal extracts such as Cannabis, Turmeric, Capsaicin, Licorice, Ginger, Chamomile, Clove, Hypericum perforatum , Arnica montana , Aloe vera and Calendula use in oral surgery pain, oral neuropathic pain, oral mucosal pain, and temporomandibular pain. The findings of this study indicate that herbal extracts may provide a valuable alternative to traditional pain medication. Additionally, it may also be a promising source for developing new active ingredients for pharmaceuticals.
The results of the study of the chloroform extract of the herb Ranunculus acris L. are presented, in particular the content of biologically active substances and antioxidant activity. 33 volatile compounds were identified: fatty acid esters, higher fatty acids, saturated hydrocarbons (alkanes), monocyclic and bicyclic monoterpenoids, etc. It was established that the chloroform extract has an antioxidant effect. In addition, the significant content of biologically active substances in the lipophilic volatile fraction of Ranunculus acris L. indicates the prospects for further research.
Ranunculus arvensis L. is a medicinal herb traditionally used for various purposes. The objective of the present research project was to find an effective and green method for obtaining bioactive natural products from it. Aqueous glycerol was employed as a green extracting medium, and the bioactive compounds were estimated as total flavonoid content (TFC) total phenolic content (TPC), antioxidant activity, and metal chelating activity (MCA). Response surface methodology (RSM) was applied to optimize the extraction process with temperature, time, and solvent (glycerol) concentration as input factors. The optimized conditions were 30 °C, 30 min, and 70% glycerol concentration at which the responses were TPC 7.15 mg gallic acid equivalents/g DW (dry weight), TFC 14.8 mg rutin equivalents/g DW, antioxidant 59.55%, and MCA 49.14%. The model was strongly supported by the validation study. The explored extraction process for bioactive natural products from R. arvensis is predictably applicable. Hence, 70% aqueous glycerol at almost room temperature and a minimum duration of 30 min can allow optimum extraction of phenolics, flavonoids, antioxidants, and metal chelators from R. arvensis.
