Figure 1 - available via license: Creative Commons Attribution 4.0 International
Content may be subject to copyright.
Source publication
Excessive bleeding can complicate surgical intervention; this could be managed using an effective hemostatic agent that provides immediate and early bleeding control. Gelatin sponge and Calendula officinalis have been proven to have good hemostatic properties. The present In-vitro study analyzed the cytotoxicity and hemostatic properties of gelatin...
Contexts in source publication
Context 1
... bar chart was plotted using the percentage of the cells that survived against the concentration of the Calendula officinalis, and the IC50 values of aliquots extracts were calculated [20] (Figure 1). ...
Context 2
... bar chart was plotted using the percentage of the cells that survived against the concentration of the Calendula officinalis, and the IC50 values of aliquots extracts were calculated [20] (Figure 1). ...
Context 3
... results showed that there was a significant difference between the groups (Fig- ures 10 and 11). Hence, the null hypothesis was rejected, and the alternate hypothesis was accepted. ...
Context 4
... the difference between the Calendula officinalis loaded gelatin sponge and the gelatin sponge alone was negligible. (Figure 11 and Table 2). ...
Context 5
... results showed that there was a significant difference between the groups (Figures 10 and 11). Hence, the null hypothesis was rejected, and the alternate hypothesis was accepted. ...
Similar publications
Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims to develop a hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes of carbonization, pur...
BACKGROUND
Transcatheter arterial embolization (TAE) is the first-line treatment for lower gastrointestinal bleeding. Previous reports have examined the safety and efficacy of TAE, but few studies have assessed its complications. Some studies have only statistically analyzed complication incidence, but it is relatively plain to discuss the causes....
Uncontrolled bleeding is linked to higher treatment costs, risk of post-surgical infection and increased disease and death. Hemostatic agents are used to treat excessive bleeding. A good hemostatic agent controls bleeding effectively, reduces the need for blood transfusion, removes the need for systemic drugs to control bleeding, results in shorter...
Background:
Some studies have recommended combining germinal matrix excision with phenol ablation in the treatment of onychocryptosis. Matrixectomy after phenolization has been shown to be an effective modification to reduce the drawbacks associated with phenolization alone, although it increases the risk of minor postoperative bleeding. The prese...
Citations
... Hence, the search for alternatives continues, and the focus has shifted toward biogenic agents. [16] This study focused on the impact of C. officinalis hydrogel surface treatment on osteoblast adhesion, proliferation, and antimicrobial efficacy against peri-implant pathogens. ...
... The amount of C. officinalis extract incorporated in hydrogel was determined both gravimetrically and spectrophotometrically (λ = 325 nm, maximum absorption corresponding to flavones and flavonols present in the plant extract [44]) as the difference between the amount of extract initially added and that found in the dried hydrogel or the washing solvent after loading procedure [45]. The extract concentration was calculated using a previously constructed calibration curve of C. officinalis in ethanol/water (50/50, v/v) (y = 0.0029x − 0.0134, R 2 = 0.9997) and the quantity of loaded Calendula in the hydrogel (loading capacity, LC) was evaluated by Equation (5): ...
The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due to their high capacity to absorb exudates and their enhanced performance in loading and releasing plant extracts. In this work, pullulan/poly (vinyl alcohol) (P/PVA) hydrogels were first prepared using an eco-friendly method based on both a covalent and physical cross-linking approach. Then, the hydrogels were loaded with the hydroalcoholic extract of Calendula officinalis by a simple post-loading immersion method. Different loading capacities were investigated in terms of the physico-chemical properties, chemical composition, mechanical properties, and water absorption. The hydrogels exhibited high loading efficiency due to the hydrogen bonding interactions between polymer and extract. The water retention capacity as well as the mechanical properties decreased with the increase in the extract amount in hydrogel. However, higher amounts of extract in the hydrogel improved the bioadhesiveness. The release of extract from hydrogels was controlled by the Fickian diffusion mechanism. Extract-loaded hydrogels expressed high antioxidant activity, reaching 70% DPPH radical scavenging after 15 min immersion in buffer solution at pH 5.5. Additionally, loaded hydrogels showed a high antibacterial activity against Gram-positive and Gram-negative bacteria and were non-cytotoxic against HDFa cells.
... Active chemical composition and material form are important factors to be considered in the development of hemostatic materials [8]. Previous studies mostly used natural polymer based materials with active components as hemostatic materials to control bleeding, such as collagen [9], gelatin [10], chitosan [11], oxidized cellulose [12], alginate [13], etc. These materials showed excellent hemostatic properties. ...
Massive hemorrhage may be detrimental to the patients, which necessitates the advent of new materials with high hemostatic efficiency and good biocompatibility. The objective of this research was to screen for the effect of the different types of bio-elastomers as hemostatic dressings. Three-dimensional (3D) loose nanofiber sponges were prepared; PU-TA/Gel showed promising potential. Polyurethane (PU) was synthesized and electrospun to afford porous sponges, which were crosslinked with glutaraldehyde (GA). FTIR and 1H-NMR evidenced the successful synthesis of PU. The prepared PU-TA/Gel sponge had the highest porosity and water absorption ratio. Besides, PU-TA/Gel sponges exhibited cytocompatibility, negligible hemolysis, and the shortest clotting time. PU-TA/Gel sponge rapidly induced stable blood clots with shorter hemostasis time and less bleeding volume in a liver injury model in rats. Intriguingly, PU-TA/Gel sponges also induced good skin regeneration in a full-thickness excisional defect model as revealed by the histological analysis. These results showed that the PU-TA/Gel based sponges may offer an alternative platform for hemostasis and wound healing.
... Hence, the search for alternatives continues, and the focus has shifted toward biogenic agents. [16] This study focused on the impact of C. officinalis hydrogel surface treatment on osteoblast adhesion, proliferation, and antimicrobial efficacy against peri-implant pathogens. ...
