Figure 1 - uploaded by Deepak Langade
Content may be subject to copyright.
Pathophysiology of diabetic neuropathy.
Source publication
Diabetes is the most common etiological factor for peripheral neuropathy (PN). While conventional
theory says that prolonged hyperglycemia results in the complications associated with diabetes,
including neuropathy, a recent study found that PN can manifest even in individuals with abnormal
glucose tolerance, a prediabetic condition. A combination...
Similar publications
ABSTRACT:
BACKGROUND:
Diabetes mellitus is a common chronic metabolic syndrome characterized by impaired metabolism of glucose; morbidity and mortality come from acute metabolic derangement and from long term complications that affect small and large vessels.
OBJECTIVE:
The assessment of the long term complications of diabetes mellitus in children...
Pancreas transplantation has emerged as an effective treatment for patients with diabetes mellitus, especially those with established end-stage renal disease. Surgical and immunosuppressive advances have significantly improved allograft survival. The procedure reduces mortality compared with diabetic kidney transplant recipients and waitlisted pati...
Diabetes mellitus (DM) is considered a major public health problem because of its high prevalence and progressive increase of incidence. DM chronic complications are major causes of morbidity and mortality, among which diabetic neuropathy (DN) stands out, affecting 30% - 50% of DM patients. An appropriate medical approach, involving anamnesis and t...
Backgrounds and aim of the work: Diabetic neuropathy is the most common complication of diabetes mellitus (DM). Diabetic peripheral neuropathy involves the presence of symptoms or signs of peripheral nerve dysfunction in people with diabetes.
Citations
... Our previous study also showed that CS was positively related to the duration of disease, and this indicates that the severity of neuropathy (CS) increases with the increasing duration of DM [1]. However, the evidence that hyperglycemia causes axonal atrophy which leads to DN is inconsistent with our findings, which showed no significant correlation between CS and HbA1c or FPG [25]. This might be because of the small scale of our study; as such, further evaluation is necessary. ...
Diabetic neuropathy (DN) is a major complication associated with diabetes mellitus (DM) and results in fatigue. We investigated whether type 2 diabetic patients with or without neuropathy experienced muscle fatigue and determined the most influencing factor on muscle fatigue. Overall, 15 out of 25 patients with type 2 DM were diagnosed with DN using a nerve conduction study in the upper and lower extremities, and the composite score (CS) was calculated. We obtained the duration of DM and body mass index (BMI) from subjects, and they underwent a series of laboratory tests including HbA1c, fasting plasma glucose, triglycerides, and high- and low-density lipoprotein. To qualify muscle fatigue, this study used surface electromyography (sEMG). Anode and cathode electrodes were attached to the medial gastrocnemius. After 100% isometric maximal voluntary contracture of plantarflexion, the root mean square, median frequency (MDF), and mean power frequency (MNF) were obtained. We showed a correlation among laboratory results, duration of DM, BMI, CS, and parameters of muscle fatigue. The duration of DM was related to fatigue of the muscle and CS (p < 0.05). However, CS was not related to fatigue. The MDF and MNF of muscle parameters were positively correlated with HbA1c and fasting plasma glucose (p < 0.05). In conclusion, we suggest that the duration of DM and glycemic control play important roles in muscle fatigue in patients with DN. Additionally, sEMG is useful for diagnosing muscle fatigue in patients with DN.
