Partial least squares–discriminant analysis (PLS-DA) of the umbilical cord plasma metabolome in comparisons 11–16. The left plots in (A–F) are the PLS-DA score plots of corresponding comparisons. Histograms on the right display the evaluation of prediction model performance via leave-one-out cross validations (LOOCV), in which R2 represents the model’s explanatory ability of the data and Q2 reflects the predictive ability of the corresponding PLS-DA model.

Partial least squares–discriminant analysis (PLS-DA) of the umbilical cord plasma metabolome in comparisons 11–16. The left plots in (A–F) are the PLS-DA score plots of corresponding comparisons. Histograms on the right display the evaluation of prediction model performance via leave-one-out cross validations (LOOCV), in which R2 represents the model’s explanatory ability of the data and Q2 reflects the predictive ability of the corresponding PLS-DA model.

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Objectives: To investigate metabolomic perturbations caused by twin-twin transfusion syndrome, metabolic changes associated with fetoscopic laser coagulation in both placental tissue and cord plasma, and to investigate differential metabolites pertinent to varying fetal outcomes, including hemodynamic status, birth weight, and cardiac function, of...

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