Table 3 - uploaded by Bui vu huy
Content may be subject to copyright.
Paediatric antiretroviral therapy (ART) utilization among children on first-line ART at data transfer in TREAT Asia and IeDEA Southern Africa
Source publication
Background: To better understand the need for paediatric second-line antiretroviral therapy (ART), an ART management survey and a cross-sectional analysis of second-line ART use were conducted in the TREAT Asia Paediatric HIV Observational Database and the IeDEA Southern Africa (International Epidemiologic Databases to Evaluate AIDS) regional cohor...
Context in source publication
Context 1
... total of 1301 children in the TREAT Asia and 4561 children in the IeDEA Southern African cohorts met inclusion criteria for the cross-sectional analysis (Tables 3 and 4). Although stavudine was infrequently used in Asia, it was part of the first-line regimen in 92% of children in southern Africa. ...
Citations
Background:
Early HIV diagnosis and enrolment in care is needed to achieve early antiretroviral treatment (ART) initiation. Studies on HIV disease stage at enrolment in care from Asian countries are limited. We evaluated trends in and factors associated with late HIV disease presentation over a ten-year period in the largest ART center in Cambodia.
Methods:
We conducted a retrospective analysis of program data including all ARV-naïve adults (> 18 years old) enrolling into HIV care from March 2003-December 2013 in a non-governmental hospital in Phnom Penh, Cambodia. We calculated the proportion presenting with advanced stage HIV disease (WHO clinical stage IV or CD4 cell count <100 cells/μL) and the probability of ART initiation by six months after enrolment. Factors associated with late presentation were determined using multivariate logistic regression.
Results:
From 2003-2013, a total of 5642 HIV-infected patients enrolled in HIV care. The proportion of late presenters decreased from 67% in 2003 to 44% in 2009 and 41% in 2013; a temporary increase to 52% occurred in 2011 coinciding with logistical/budgetary constraints at the national program level. Median CD4 counts increased from 32 cells/μL (IQR 11-127) in 2003 to 239 cells/μL (IQR 63-291) in 2013. Older age and male sex were associated with late presentation across the ten-year period. The probability of ART initiation by six months after enrolment increased from 22.6% in 2003-2006 to 79.9% in 2011-2013.
Conclusion:
Although a gradual improvement was observed over time, a large proportion of patients still enroll late, particularly older or male patients. Interventions to achieve early HIV testing and efficient linkage to care are warranted.
Two hundred fifty seven articles related to HIV/AIDS were
found in a search through a database dedicated to indexing
all original data relevant to medicine published in Malaysia
between the years 2000–2013. One hundred seventy one
articles were selected and reviewed on the basis of clinical
relevance and future research implications. This review of
literature has been divided into six sections, namely,
epidemiology, risk behaviour, clinical features and
opportunistic infections, management, diagnosis and
discussion. Wherever possible, the reviewed articles have
been presented in a chronological order to provide a historical
perspective to the reader as many of the results of earlier
publications, which are common knowledge now, were
relatively unknown then. Since the early days of the HIV
epidemic in Malaysia, there have been rapid advances in the
understanding and the management of the epidemic in
Malaysia based on the insights derived from the results of
these research. These insights are invaluable tools for policy
makers, advocators, healthcare providers, researchers and
everyone and anyone who are involved in the care of
individuals with HIV/AIDS. Attempts have been made to
identify gaps in certain research areas with the hope of
providing directions for future research in HIV/AIDS in
Malaysia.
