Fig 2 - uploaded by Sushil Kumar
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PS-dependent recognition of apoptotic cells: Apoptotic cells expressing PS are recognized by various receptors present on phagocytes that include BAI1, Stabilin-2, TIM1, 3, 4, Tyro, Axl, Mer, SCARF1 and Vitronectin receptors
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Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in the biology of life, by removing unwanted cells that have reached advanced age or whose genomes have been irreparably damaged, as well as by sculpting complex structures during embryogenesis. Apoptosis culminates in the rapid and decisiv...
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Context 1
... fully understood, the externalization of phosphatidylserine (PS) is arguably the most emblematic event associated with apoptosis, and PS clearly serves as recognition module for a variety of receptors and serum proteins that contribute to efferocytosis (Krahling, Callahan et al. 1999, Schlegel, Callahan et al. 2000) (Fadok, Voelker et al. 1992) (Fig. 2). Indeed, many of the PS receptors described in Fig. 2, such as MFG-E8, TIM-1, TIM-4, MERTK, C1q, and SCARF1, when targeted by knockout in mice, result in an impaired capacity to clear apoptotic cells in vivo, validating the centrality of PS externalization as a central recognition cue for efferocytosis in metazoans. among others. These ...
Context 2
... (PS) is arguably the most emblematic event associated with apoptosis, and PS clearly serves as recognition module for a variety of receptors and serum proteins that contribute to efferocytosis (Krahling, Callahan et al. 1999, Schlegel, Callahan et al. 2000) (Fadok, Voelker et al. 1992) (Fig. 2). Indeed, many of the PS receptors described in Fig. 2, such as MFG-E8, TIM-1, TIM-4, MERTK, C1q, and SCARF1, when targeted by knockout in mice, result in an impaired capacity to clear apoptotic cells in vivo, validating the centrality of PS externalization as a central recognition cue for efferocytosis in metazoans. among others. These PS receptors either bind PS directly or indirectly ...
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