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PPIN of Selected DEGs. Edges number: 378, average node degree: 3.58, average local clustring coefficient: 0.323, PPI enrichment pValue<10 -16 . Yellow nodes: Significant modules. Module 1 (Right): MMP1, CXCL8, EGR1, PI3, PTGS2, MMP7, CXCR4, CTGF. Module 2 (Left): AKR1C3, LCN2, CCL20, VCAN, IGFBP7, LUM, ALDH3A, CYP1B1, AKR1C2, AKR1C1.
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Introduction: Gene expression profiling has high potential in the identification of diagnostic, predictive, and therapeutic gene targets in human cancers such as colorectal cancer (CRC). Accordingly, in this study, an integrated systems biology analysis was done on several microarray datasets to identify key genes involved in CRC chemoresistance an...
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... PPIN was constructed using STRING (PPI enrichment pValue<10 -16 ). The network analyzing was performed using Cytoscape ( Figure 3) and 30 top DEGs (nodes) with highest score for each of betweenness centrality, closeness centrality, degree, neighborhood connectivity and radiality parameters were selected. Four hub genes were identified with high scores in terms of betweenness centrality, closeness centrality, degree, neighborhood connectivity and radiality using interactive vendiagram (Figure 4, two asterisk in Table 4). ...
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Background
Circular RNA (circRNA) plays an important role in the regulation of gene expression and the occurrence of human diseases. However, studies on the role of circRNA in acute myocardial infarction (AMI) are limited. This study was performed to explore novel circRNA-related regulatory networks in AMI, aiming to better understand the molecular...
Citations
... This concentration is relatively higher than conventional anticancer drugs. Two standard chemotherapeutic drugs commonly used in the treatment of colorectal cancer are 5-Fluorouracil (5-FU), and oxaliplatin (OXA) (Manoochehri et al., 2022). The IC50 for 5-FU in different colorectal cancer cell lines including HCT116 (used in this study) reported in a range between 0.6 and 4 μg/ml (Varghese et al., 2019). ...
In this work, magnetic poly(aniline-co-melamine) nanocomposite as an efficient heterogeneous polymer-based nanocatalyst was fabricated in two steps. First, poly(aniline-co-melamine) was synthesized through the chemical oxidation by ammonium persulfate, then the magnetic nanocatalyst was successfully prepared from the in-situ coprecipitation method in the presence of poly(aniline-co-melamine). The resulting poly(aniline-co-melamine)@MnFe2O4 was characterized by FTIR, FESEM, XRD, VSM, EDX, TGA, and UV-vis analyses. The catalytic activity of poly(aniline-co-melamine)@MnFe2O4 was investigated in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives in excellent yields. The yield of 1,4-dihydropyrano[2,3-c]pyrazoles, 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), yields, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives were obtained 89%–96%, 90%–96%, and 92%–96%, respectively. The poly(aniline-co-melamine)@MnFe2O4 nanocatalyst can be recycled without pre-activation and reloaded up to five consecutive runs without a significant decrease in its efficiency. In addition, the antioxidant activity of some derivatives was evaluated by DPPH assay. Results showed that the maximum antioxidant activity of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles were 75% and 90%, respectively. Furthermore, 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles showed good potential for destroying colon cancer cell lines. Consequently, the poly(aniline-co-melamine)@MnFe2O4 nanocomposite is an excellent catalyst for green chemical processes owing to its high catalytic activity, stability, and reusability.
