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Oviduct morphometric analysis. Muscle layer thickness and epithelium heights (µm) of isthmus and ampulla. Untreated control and 50 ppm, 100 ppm, and 200 ppm arsenite-treated rat groups.
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Arsenic-contaminated drinking water and its association to different diseases has been considered a severe problem worldwide. The goal of the present study was to evaluate the histopathological changes in oviduct of female rat following 4-week exposure to different doses (50, 100, and 200 ppm) of sodium arsenite. Treatment was initiated when rat re...
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... and epithelium thickness of ampulla and isth- mus was reduced significantly from low to high in a dose-dependent manner compared to control group and reported in Table 1. The 200 ppm-treated group showed greatest reduction in muscle layer thickness and height of ampulla and isthmus epithelium as com- pared to 50 ppm and 100 ppm groups (Figure 9). ...Similar publications
A recyclable NiFe2O4 was synthesized and applied to the removal of As(V) from arsenic-contaminated solutions by calcining Ni/Fe layered double hydroxides (LDHs) through in situ growing on nickel foam (NF). The NiFe-LDHs/NF and NiFe2O4/NF exhibited typical hierarchically porous platelet-like structures. The adsorption kinetics, isotherms, and adsorp...
Citations
... Histological assessment was done as described by Akram et al. (2018). Tissues were fixed in a mixture of ethanol (60 ml), formaldehyde (30 ml), and glacial acetic acid (10 ml) for 24-48 h, and then proceeded for O n l i n e F i r s t A r t i c l e embedding in paraffin. ...
... The animals in the fourth group received CA (60 mg/kg body weight; i.p.). Dose selection in the current study as well as the route of preparation and administration of chemicals were based on previously published works for arsenite [27][28][29] and caffeic acid [15,16]. ...
Arsenic (As) is an environmental pollutant with destructive effects on different body organs, including the testis. This work was aimed to assess the ameliorative role of caffeic acid (CA) against As-provoked testicular damage in mice. Twenty-four adult male mice (31 ± 9 g) were randomly allocated to four equal groups. The first group served as control and was provided basal diet and tap water. Animals in the second group received water containing 200 ppm arsenite. The third group of mice received CA (60 mg/kg body weight; i.p.) during exposure to arsenite. Animals in the fourth group received CA. At the end of the experiment period (21 days), blood and testicular tissue sampling was done for biochemical and histopathological assessments. The results showed a significant decline of testicular ferric reducing antioxidant power (FRAP), superoxide dismutase, and glutathione peroxidase (GPx), as well as plasma concentrations of testosterone and dihydrotestosterone in As-treated mice compared to controls (p < 0.05). A significant increase in testicular malondialdehyde was also detected in group 2 relative to controls. Moreover, As exposure resulted in some morphological and histopathological alterations of the testis, including hyperemia, reduced tubular diameter and thickness of epithelial cell layers of seminiferous tubules, and Leydig cell necrosis. Simultaneous administration of CA plus As increased GPx, FRAP, testosterone, and dihydrotestosterone amounts and attenuated MDA levels as well as histopathological alterations to the levels that were not significantly different from those of the control group. These results indicate that caffeic acid can be suggested as an alleviative natural compound against As-induced damage in mice testes.
... In adult females, exposure to arsenic induced alterations in reproductive organs morphology, estrous cycle duration, sexual hormones levels and antioxidant enzymes activities of uterus and ovaries (Akram, Jalali, Kalsoom, Batool, & Shami, 2018;Deb et al., 2018;Mehta & Hundal, 2016). Although the exact mechanism of action of this metalloid is still unclear, many studies suggested that reactive oxygen species and reactive nitrogen species are generated during inorganic arsenic metabolism in the cells inducing oxidative and nitrosative stress (as reviewed by Jomova et al., 2011). ...
Heavy metals are widely used for industrial and agricultural purposes. Humans are mainly exposed to heavy metals through the consumption of contaminated water, food, and inhalation of industrial dust. The industrial waste discharge also increases the toxic level of heavy metals in water resources. The toxic effects of heavy metals are reported at higher doses in in vivo experimental models. However, low levels of these metals have a negative impact on human health. In the current chapter, we discussed the effects of heavy metals on the male and female reproductive system along with developmental effects. The reproductive toxicity studies deal with the target of the metals in the gonads, whereas the developmental toxicity covers the effects of the metals on the fertilized ovum, embryo, fetus, and offspring. We have elaborated the mechanisms associated with heavy metals induced reproductive and developmental toxicity considering preclinical and clinical research. We have also explained the beneficial effects of antioxidants and chelation therapy during heavy metals induced reproductive and developmental toxicity.
