Overview of signal transduction pathways involved in apoptosis. Mutations leading to loss of apoptosis can lead to tumorigenesis. 

Context in source publication

Context 1

... cells will commit cell suicide (apoptosis) when they are no longer needed. Until then, they are protected from cell suicide by several protein clusters and pathways ( Figure 2). One of the protective pathways is the PI3K/AKT pathway; another is the RAS/MEK/ERK pathway. ...