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Ovarian tissue stained with H&E ((a): atretic follicle, (b): antral follicle and (c): corpus luteum) (4 weeks after treatment, control group).
Source publication
Objectives:
This study investigates the therapeutic effect of vitamin C on the development of endometrial lesions and fecundity disorders in the ovarian induction model of mouse endometriosis.
Methods:
Ovarian endometriosis was surgically induced in 14 NMRI female mice (treatment group, N = 7) and (control group, N = 7). Three days after the sec...
Citations
... Other interesting observations regarding the role of antioxidant vitamins in endometriosis were presented in animal models; however, the authors analyzed their actions separately. Vitamin C, in addition to suppressing the growth of endometriosis lesions [53][54][55], has been mentioned as a vitamin intensifying the apoptosis [56] and degeneration of atretic follicles [53]. Similarly, the beneficial properties of vitamin E were shown in the study by Ni et al. using a mouse model. ...
... Other interesting observations regarding the role of antioxidant vitamins in endometriosis were presented in animal models; however, the authors analyzed their actions separately. Vitamin C, in addition to suppressing the growth of endometriosis lesions [53][54][55], has been mentioned as a vitamin intensifying the apoptosis [56] and degeneration of atretic follicles [53]. Similarly, the beneficial properties of vitamin E were shown in the study by Ni et al. using a mouse model. ...
Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.
... ROS, which are unstable molecules, engage with biological molecules, triggering apoptotic mechanisms and cell death [13]. Antioxidants have been employed to alleviate pain in various conditions, demonstrating their ability to reduce nociception mediated by free radicals [14]. Existing literature on antioxidant therapy indicates that the positive attributes of antioxidants may alleviate symptoms of endometriosis-related pain and mitigate oxidative damage [15]. ...
... Both animal and human studies indicate that consuming fruits, vegetables, or antioxidant supplements can effectively decrease oxidative stress markers [14,[17][18][19]. For example, a study by Mier-Cabrera et al., demonstrated that vitamins C and E supplementation resulted in a decrease in oxidative stress markers (MDA and lipid hydroperoxides) in women with endometriosis [18]. ...
Introduction: Endometriosis is a chronic condition characterized by the presence of endometrial-like tissue outside the uterus, which causes estrogen-induced inflammation. Pelvic severe pain, dysmenorrhea, and dyspareunia are known as the most common symptoms in endometriosis patients. Antioxidants can help alleviate endometriosis-related pain. However, the mechanism is not fully understood. A study is needed to elucidate the inherent potential of an antioxidant in women with endometriosis. Material and Methods: The literature search was conducted in two databases. The outcome of interest is to measure mean changes based on pain severity using the VAS score in endometriosis-related pain, including dysmenorrhea, pelvic pain, and dyspareunia. Some of the antioxidant agents formed in this study are vitamin D, vitamin C, vitamin E, livergol (silymarin), garlic tablets, resveratrol, and melatonin compared to placebo. Meta-analysis was done using RevMan 5.4 using mean change from baseline data with their 95% confidence intervals (CI) provided. Results: Twelve studies meeting the inclusion criteria were considered relevant for assessing the potencies of antioxidants in endometriosis patients (n=695). The antioxidant group had significantly better pelvic pain improvement (MD: -2.21, 95%CI: -3.40 to -1.03, p=0.0003), reduction in dyspareunia symptoms (MD: -1.47, 95% CI: -2.68 to -0.27, p=0.02) as well as improvement in dysmenorrhea with a mean difference -1.92 (95% CI: -3.41 to -0.43, p=0.01) than the placebo group. Antioxidants showed excellent potential to be an alternative treatment in managing endometriosis-related pain, particularly pelvic pain, dyspareunia, and dysmenorrhea. Conclusion: The efficacy of antioxidant agents can be a potential treatment to alleviate pain associated with endometriosis, such as pelvic pain, dysmenorrhea, and dyspareunia.
... However, increasing evidence from animal studies indicates the inhibitory effect of vitamin C supplementation on lesions associated with endometriosis [34][35][36][37]. In such experiments, investigators used various parameters to describe the appearance of ectopic endometrial tissue, such as the size, volume, and mass of the lesions, as well as various assessments related to associated adhesions, assessment of fibrosis, and the condition of the mucosa associated with the lesion epithelium. ...
... In such experiments, investigators used various parameters to describe the appearance of ectopic endometrial tissue, such as the size, volume, and mass of the lesions, as well as various assessments related to associated adhesions, assessment of fibrosis, and the condition of the mucosa associated with the lesion epithelium. Although all authors consistently observed the inhibitory effect of vitamin C, which was reflected in a decrease in the above-mentioned parameters describing the lesions, the only parameter in all the analyzed studies that underwent significant changes in the groups supplemented with vitamin C was the volume of lesions [34][35][36][37]. ...
Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.
... In contrast, Amini et al. confirmed the effect of a decrease in systemic oxidative stress markers in endometriosis patients taking vitamins C and E [46]. In contrast, other researchers have provided evidence of vitamin C's relationship to a reduction in endometrial implant induction and growth, and to improved fertility [47]. ...
Aim: To assess knowledge of the SARS-CoV-2 virus and attitudes toward the pandemic among patients in seven European countries in the opinion of medical personnel. Material and methods: The research was conducted across seven European countries. The questionnaire included questions relating to the Covid-19 pan¬demic regarding medical personnel’s opinions on the level of patient education, the sharing of incorrect information by patients, the following of quarantine procedures by patients, and the necessity of introducing tighter sanitary restrictions. Results: The research indicated significant differences between countries in the answers provided by medical personnel. Medical personnel encountered the sharing of incorrect information by patients most often in Poland, and most seldom in Norway. Staff in the United Kingdom and Poland had the lowest as¬sessment of patients following quarantine procedures, while personnel in Norway had the most positive assessment in this area. Education of the patients on the SARS-CoV-2 virus was most positively assessed by personnel in Finland, and the most poorly by staff from Poland. The necessity to impose tighter sanitary restrictions was indicated by the greatest number of personnel in Poland and the United Kingdom, and by the lowest number in Spain. Conclusions: The research indicated significant differences between countries in the provided answers. The study also demonstrated that as a rule the sanitary restrictions were supported.
... Hoorsan et al. [115], based on their findings in mice, concluded that vitamin C could improve ovarian function and reduce the induction and growth of endometrial grafts. Similar conclusions were reached in a study on rats. ...
Endometriosis is a chronic disease with a complex, heterogeneous pathogenesis that affects about 10% of women of reproductive age, causing pain and leading to infertility. Treatment consists of administering pharmacological agents (resulting in a reduction of estrogen levels and inflammation), as well as the surgical removal of endometriotic lesions. Unfortunately, despite a wide range of available therapies, there is still a high recurrence rate after surgery. Consequently, it is necessary to improve the outcome of patients with endometriosis. In this context, there is growing interest in possible dietary modification to support or complement classic treatment options and even serve as a potential alternative to hormone therapy. In addition, a growing number of studies indicate positive effects of selected dietary factors on the development and course of endometriosis. This review article focuses on the potentially beneficial effects of compounds from the polyphenol group (curcumin, epigallocatechin gallate, quercetin, resveratrol), vitamins, and selected micronutrients on endometriosis. The results indicate the potential of the selected ingredients in fighting the disease. However, most of the studies have been performed on experimental animal models, with a smaller proportion looking at the actual effects of use among women. Therefore, well-designed studies are needed to assess the importance of a well-chosen diet and the effects of specific dietary factors on the health of women suffering from endometriosis.
... In contrast, Amini et al. confirmed the effect of a decrease in systemic oxidative stress markers in endometriosis patients taking vitamins C and E [46]. In contrast, other researchers have provided evidence of vitamin C's relationship to a reduction in endometrial implant induction and growth, and to improved fertility [47]. ...
Aim: To assess the impact of the pandemic on the number and mode of admissions and diagnoses in emergency patients transferred by emergency medical services. Material and methods: Data provided by the National Health Fund on the number and mode of hospital admissions and diagnoses according to Uniform Patient Group sections A C D E F G H J K L M Q S for patients admitted in an emergency after being transferred by emergency medical services between March 1 and December 31, 2020 were assessed. The data were analysed by month and compared with the report for the period of March 1 to December 31, 2019. Results: In the analysed period in 2020, the number of hospital admissions dropped by 79,867 cases (17.90%), including by 72,784 (21.14%) for conservative cases and by 7,083 (6.96%) for invasive cases. The highest number of hospital admissions was recorded in March (41,505, 11.33%), including conservative cases (32,005, 11.79%), and the highest number of surgical admissions was seen in July (10,799, 11.39%). In November, the largest decrease in the number of admissions (28,763, 7,85%), including conservative (21,140, 7.78%) and surgical (7,623, 8.04%) admissions, and the number of ICD-10 diagnoses in sections A, C, E, F, G, H , J, K, L, Q, and in sections D and S was recorded in April. Conclusions: The number of conservative and surgical hospital admissions decreased in the investigated period.
... In contrast, Amini et al. confirmed the effect of a decrease in systemic oxidative stress markers in endometriosis patients taking vitamins C and E [46]. In contrast, other researchers have provided evidence of vitamin C's relationship to a reduction in endometrial implant induction and growth, and to improved fertility [47]. ...
Aim: The COVID-19 pandemic is still a real threat to global public health. Medical personnel face new, previously unencountered challenges, and their feel¬ing of physical and psychological safety is under threat. The aim of the paper is to examine the differences in the feeling of safety among emergency medical personnel during the COVID-19 pandemic in selected European countries. Material and methods: The study group consisted of 1984 people working in the emergency medical services in seven countries. The research tool was a proprietary internet questionnaire, which prior to commencement of the research was validated using the Mc-Donald test, achieving a result of > 0.7, which underlines a satisfactory level of reliability. In the statistical analysis, a significance level of p = 0.05 was adopted. Analysis of the quantitative variables, presented by division into groups, was conducted using the non-parametric Mann-Whitney and Kruskal-Wallis tests. The choice of tests was conducted on the basis of the distribution of variables, verified by the Shapiro-Wilk test. Results: During the COVID-19 pandemic, the feeling of safety among employees of the emergency medical services and the feeling of danger to health and life as a result of infection with the SARS-CoV-2 virus was varied and depended on the job position. Principles for observing the sanitary regulations and the level of fear of infection are at a similar level and depend on place of work. Conclusions: Those most at risk from a lack of safety are emergency medical response teams.
... In contrast, Amini et al. confirmed the effect of a decrease in systemic oxidative stress markers in endometriosis patients taking vitamins C and E [46]. In contrast, other researchers have provided evidence of vitamin C's relationship to a reduction in endometrial implant induction and growth, and to improved fertility [47]. ...
Aim: Indication of appropriate treatment of the emergency medical team towards a patient with acute pericarditis being a life-threatening condition. Material and method: The retrospective study included two men to whom EMT (Emergency Medical Team) was called for chest pain and in the second case due to the correlation of chest pain, ECG changes and pathological results of ultrasensitive cardiac troponin and CRP. Both patients developed acute pericarditis as a result of the infection they were currently undergoing. In this paper, the case study method was used. The research material was obtained through the analysis of medical rescue cards, EMT departure order cards and hospital treatment information cards. Conclusions: Among cardiac patients with stenocardial pain, regardless of age and other factors, an examination should always be carried out and discriminatory diagnostics should be implemented, m.in. for suspected acute pericarditis. Medical interview, in particular epidemiological history, plays an important role.
... Hoorsan et al., in their experiment on mice, suggested that vitamin C has considerable importance for improving the fecundity function of ovaries and reducing the induction and growth of endometrial implants [44]. ...
Endometriosis is a chronic, painful, estrogen-related inflammatory disease that affects approximately 10% of the female population. Endometriosis has a significant negative impact on quality of life. Nutrition may be involved in the development and severity of endometriosis. The purpose of this paper is to discuss in detail the nutritional recommendations for patients with endometriosis. This article discusses the importance of nutrients such as polyphenols, vitamins C, D and E, PUFAs, and iron in the development of endometriosis. Alternative diets, such as the Mediterranean, anti-inflammatory, vegetarian, low-nickel and low-FODMAP diets, have also been presented in the context of their potential beneficial effects on the course of endometriosis.
... To date, various rodent models of endometriosis have been established to elucidate its pathophysiology [5][6][7][8] and to test the efficacy of the treatment [9][10][11]. On the other hand, only a few rodent models have been reported to evaluate endometriosis-related adverse perinatal outcomes [12][13][14][15][16]. ...
The purpose of this study was to establish a new mouse model of endometriosis that mimics real-world women’s health problems, in which women continue to be affected by endometriosis long before they wish to become pregnant, and to evaluate the impact of “chronic exposure to endometriosis” on perinatal outcome. Endometriosis was established by the intraperitoneal injection of homologous minced mouse uteri. Vehicle was injected for the control. Mating was initiated either 1 or 43 days after disease establishment (Young or Aged studies, respectively). Mice were sacrificed on 18 dpc. The number pups and resorptions were counted and pups’ body weights (BW) were measured, and the endometriosis lesion was identified and weighted. In the Young study, the number of resorptions and BW were comparable between the groups. In the Aged study, the number of resorptions was significantly higher and BW was significantly lower in endometriosis than that in control. The total weight of endometriosis lesion per dam was significantly lower in the Aged compared to the Young endometriosis group; however, not a single mouse was found to have any lesions at all. These results suggest that in addition to the presence of endometriosis per se, “chronic exposure to endometriosis” prior to pregnancy affect perinatal outcomes.
