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Opened radical circumcision specimen showing tumour on inner mucosal surface. Vertical bars indicate orientation for block taking
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Background
To test the effect of variant histology relative to urothelial histology on stage at presentation, cancer specific mortality (CSM), and overall mortality (OM) after chemotherapy use, in urethral cancer.
Materials and Methods
Within the Surveillance, Epidemiology and End Results (2004–2016) database, we identified 1,907 primary variant h...
Purpose
Urethral carcinoma (UC), as a rare tumor, is not widely studied. There have been no systematic studies of rare pathological types of UC. We conducted this study to further investigate rare pathological types of primary urethral carcinoma (PUC).
Materials and methods
We used the population-based Surveillance, Epidemiology, and End Results (...
Background
Primary urethral carcinoma (PUC) is rare and accounts for < 1% of all genito-urinary cancers. There is a male predominance of 3:1 and a peak incidence in the 7th and 8th decades. The aetiology of this cancer is similar to penile cancer, and the human papilloma virus (HPV) is thought to be an essential factor in tumorigenesis. Urethral ca...
We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathological diagnosis was amelanotic malignant melanoma of...
Simple Summary
This suggested paper aims to comprehensively address the assessment of urethral mesh in oncologic patients, a common surgical intervention for stress urinary incontinence. Acknowledging the procedure’s benefits along with its potential complications, we seek to present a comprehensive review encompassing normal MR and CT appearances...
Citations
... Penile cancer is the rarest of the urological cancers covered by the TNM staging system and there have been a number of significant papers and guidelines produced in the intervening time between the publication of the 7 th edition of the UICC staging classification and UICC 8. 3,30 Unfortunately, with the exception of the modification of the T2 and T3 stages, which are the same in UICC 8 and AJCC 8, the advances documented in the literature do not seem to have been taken into account in UICC 8. ...
... The recognition and subclassification of PeIN is important in assigning appropriate treatment 31 and as such the term carcinoma in situ is not generally used in current reporting. 30 The category pTa was specified as 'non-invasive verrucous carcinoma' in the 7th edition of the UICC staging classification and this is unchanged in UICC 8. The AJCC now specifies this category as noninvasive squamous carcinoma and does not indicate any subtypes. ...
... There is no evidence base for the entity 'non-invasive verrucous carcinoma' in the literature and it is recommended in the Royal College of Pathologists guidelines that this category is not used as it may lead some inexperienced pathologists to call verrucous carcinomas of the penis non-invasive, when the vast majority of them are invasive. 3,30 pT1a and pTIb are defined by the degree of differentiation and/or the presence of lymphovascular invasion in the 7th edition of the UICC staging classification but in the AJCC 8 an additional prognostic indicator, perineural invasion has been added. Perineural invasion is not included in UICC 8 which is a serious omission, as there is good evidence to show that perineural invasion affects prognosis. ...
The publication of each successive edition of the TNM staging classification by the International Union Against Cancer (UICC) is widely anticipated, as the staging system is accepted and utilized internationally. Late in 2016 the eighth edition of the TNM classification (UICC 8)(1) was released but unfortunately, and despite the passage of six years since the publication of the seventh edition of the staging classification, the new edition incorporates little new data. In addition to this there are a number of differences between the staging recommendations of UICC 8 and those recently published as part of the 8(th) edition of the American Joint Committee for Cancer (AJCC 8). This article is protected by copyright. All rights reserved.
... 26 Squamous carcinoma of the distal penile urethra is covered in the RCPath's Dataset for Penile and Distal Urethra Cancer Histopathology Reports. 27 ...
Background:
Stage at diagnosis is a strong predictor of cancer survival. Differences in stage distributions and stage-specific management help explain geographic differences in cancer outcomes. Stage information is thus essential to improve policies for cancer control. Despite recent progress, stage information is often incomplete. Data collection methods and definition of stage categories are rarely reported. These inconsistencies may result in assigning conflicting stage for single tumours and confound the interpretation of international comparisons and temporal trends of stage-specific cancer outcomes. We propose an algorithm that uses multiple routine, population-based data sources to obtain the most complete and reliable stage information possible.
Methods:
Our hierarchical approach derives a single stage category per tumour prioritising information deemed of best quality from multiple data sets and various individual components of tumour stage. It incorporates rules from the Union for International Cancer Control TNM classification of malignant tumours. The algorithm is illustrated for colorectal and lung cancer in England. We linked the cancer-specific Clinical Audit data (collected from clinical multi-disciplinary teams) to national cancer registry data. We prioritise stage variables from the Clinical Audit and added information from the registry when needed. We compared stage distribution and stage-specific net survival using two sets of definitions of summary stage with contrasting levels of assumptions for dealing with missing individual TNM components. This exercise extends a previous algorithm we developed for international comparisons of stage-specific survival.
Results:
Between 2008 and 2012, 163 915 primary colorectal cancer cases and 168 158 primary lung cancer cases were diagnosed in adults in England. Using the most restrictive definition of summary stage (valid information on all individual TNM components), colorectal cancer stage completeness was 56.6% (from 33.8% in 2008 to 85.2% in 2012). Lung cancer stage completeness was 76.6% (from 57.3% in 2008 to 91.4% in 2012). Stage distribution differed between strategies to define summary stage. Stage-specific survival was consistent with published reports.
Conclusions:
We offer a robust strategy to harmonise the derivation of stage that can be adapted for other cancers and data sources in different countries. The general approach of prioritising good-quality information, reporting sources of individual TNM variables, and reporting of assumptions for dealing with missing data is applicable to any population-based cancer research using stage. Moreover, our research highlights the need for further transparency in the way stage categories are defined and reported, acknowledging the limitations, and potential discrepancies of using readily available stage variables.
