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Observed versus predicted plots of multiple linear regression model for increased EQ-5D score from week 0 to week 48
Source publication
Purpose:
No study has investigated the clinical and radiographic risk factors for the deterioration of quality of life (QOL) beyond 6 months after osteoporotic vertebral fractures (OVF). The purpose of this study was to identify the predictors associated with poor QOL improvement after OVF.
Methods:
This post hoc analysis included 166 women aged...
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Background:
Malnutrition at admission is associated with complication-related readmission and prolonged hospital stay. This underscores the importance of an adequate intake - more particular, protein intake - to prevent further deterioration and treat malnutrition during hospitalization. Our objective was to assess whether protein intake relative...
Citations
... Decreased activity associated with VFs not only causes pain but also increases loneliness. Moreover, it can lead to depression [14], which has a significant impact on the QOL and longevity of elderly individuals. ...
(1) Background: Patients with primary vertebral fracture (VF) are at high risk of re-fracture and mortality. However, approximately two-thirds of patients with VFs receive minimal clinical attention. (2) Methods: The current study aimed to investigate the factors associated with asymptomatic VFs in middle-aged and elderly individuals who underwent resident health examinations. (3) Results: The current study included 217 participants aged > 50 years. VFs were diagnosed based on lateral radiographic images using Genant’s semiquantitative (SQ) method. The participants were divided into non-VF (N; SQ grade 0) and asymptomatic VF (F; SQ grades 1–3) groups. Data on body composition, blood tests, quality of life measures, and radiographic parameters were assessed. A total of 195 participants were included in the N group (mean age, 64.8 ± 7.8 years), and 22 were in the F group (mean age, 66.1 ± 7.9 years). The F group had a significantly higher body mass index (BMI), body fat percentage (BF%), and proportion of patients with knee osteoarthritis (KOA) than the N group. The F group had a significantly higher knee joint pain visual analog scale (VAS) score and painDETECT score than the N group. Logistic regression analysis showed that BF% was associated with asymptomatic VFs. (4) Conclusions: Middle-aged and elderly individuals with asymptomatic VF presented with high BMIs, BF%, and incidence of KOA.
... Moreover, with osteoporosis, minor trauma can lead to fractures, which could subsequently lead to pain and even impairment in the patient's quality of life. (2)(3)(4)(5) Recent advances in molecular biology have led to advances in the drug treatment of osteoporosis, including the development of bisphosphonates to inhibit bone resorption and teriparatide from promoting bone formation. (6) However, bisphosphonates have the disadvantage of inhibiting bone formation as well as bone resorption, while teriparatide promotes bone resorption as well as bone formation. ...
Excluding clinical trials, there is limited evidence on the effect of 12 months of romosozumab treatment on bone mineral density (BMD) increase in real‐world clinical practice because its use has only been approved recently. Thus, this study aimed to investigate the real‐world effect of 12 months of romosozumab treatment on BMD increase and identify factors that predict the rate of BMD increase after 12 months of romosozumab treatment. We retrospectively investigated 106 patients who completed a 12‐month romosozumab treatment for osteoporosis with a high risk of fractures at four hospitals from March 2020 to March 2022. The univariate and multiple regression analyses were performed to analyze the concurrent effects of various factors on the BMD increase after the 12‐month romosozumab treatment. After 1 year of treatment, the lumbar spine BMD increased by 14.6%, and femoral neck BMD increased by 5.1%. Univariate regression analysis found that male sex, high tartrate‐resistant acid phosphatase 5b (TRACP‐5b) value before romosozumab administration, absence of osteoporosis medications before romosozumab administration, and low baseline lumbar spine BMD were associated with the extent of lumbar spine BMD increase. Moreover, stepwise multiple regression analysis found that the TRACP‐5b value before romosozumab administration was a significant predictor of the rate of lumbar spine BMD increase after 1 year of romosozumab administration. In conclusion, our results demonstrated the effectiveness of the 12‐month romosozumab treatment for osteoporosis with a high risk of fractures and the TRACP‐5b value before romosozumab administration was a significant predictor of the rate of lumbar spine BMD increase after 1 year of romosozumab administration. Our findings could help establish more efficient treatment strategies for patients with osteoporosis at a high risk of fracture. This article is protected by copyright. All rights reserved.
... As society ages, the number of patients with OVFs is expected to increase. In the acute phase after OVF, patients experience severe low back pain and deterioration in their quality of life [3]. Although most vertebral fractures improve with time, some patients continue to have low back pain even after the acute phase, and their quality of life continues to decline [4,5]. ...
Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable.
Osteoporotic vertebral compression fractures (OVCFs) are the most common type of osteoporotic fracture. Severity is assessed by determining the extent of vertebral height reduction and morphologic change. The main symptom is pain. But two-thirds of OVCFs are clinically silent and less than 10% require hospital admission. Radiographs are the only modality really necessary for diagnosis. MRI is the study of choice to determine the acuity of the fracture. To date, there is no gold standard treatment for these fractures. Conservative treatment is considered the first option. If pain continues after 6 weeks of non-surgical therapy, cementation techniques such as kyphoplasty or vertebroplasty are good options. Surgical decompression and stabilization are indicated in cases of progressive neurological deficit, as well as in cases of posterior longitudinal ligament injury and unstable spine.
To reduce the risk of posterior vertebral fractures, we work as a team with the endocrinologist and evaluate the best therapeutic scheme.
