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![Neuroimaging aspects of Cobalamin deficiency [9, 49, 60]. A and B: T2 Medullary MRI showing the V-inverted sign as a hypersignal of the posterior cords on axial (A) and an extended medullary cervical hypersignal on sagittal (B) [60]. C and D: T2 FLAIR Brain MRI axial sections. Showing symmetrical hypersignals of the dorsolateral brainstem regions (C) [49]. And diffuse and symmetrical hypersignal of the periventricular white matter in a 45-year-old woman with progressive cognitive decline (D) [9].](profile/Saddek-Khellaf/publication/343636595/figure/fig1/AS:924128156606466@1597340730346/Neuroimaging-aspects-of-Cobalamin-deficiency-9-49-60-A-and-B-T2-Medullary-MRI.png)
Neuroimaging aspects of Cobalamin deficiency [9, 49, 60]. A and B: T2 Medullary MRI showing the V-inverted sign as a hypersignal of the posterior cords on axial (A) and an extended medullary cervical hypersignal on sagittal (B) [60]. C and D: T2 FLAIR Brain MRI axial sections. Showing symmetrical hypersignals of the dorsolateral brainstem regions (C) [49]. And diffuse and symmetrical hypersignal of the periventricular white matter in a 45-year-old woman with progressive cognitive decline (D) [9].
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![Figure 2: Neuroimaging aspects of Cobalamin deficiency [9, 49, 60]. A...](profile/Saddek-Khellaf/publication/343636595/figure/fig1/AS:924128156606466@1597340730346/Neuroimaging-aspects-of-Cobalamin-deficiency-9-49-60-A-and-B-T2-Medullary-MRI_Q320.jpg)
![Figure 3: Diagnostic approach to vitamin B12 deficiency [1, 25].](profile/Saddek-Khellaf/publication/343636595/figure/fig2/AS:924128156606468@1597340730403/Diagnostic-approach-to-vitamin-B12-deficiency-1-25_Q320.jpg)
Cobalamin or Vitamin B12 deficiency is common and underdiagnosed in adults. It should be looked for, in addition to the classical hematological presentation, in patients with suggestive neurological signs such ataxia, paresthesia or cognitive impairment, particularly in populations at risk, such as elderly, alcoholic, vegetarian or malnourished. Th...
