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Natamycin or pimaricin (E235) structure.  

Natamycin or pimaricin (E235) structure.  

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Food additives are natural or synthetic substances that can be added to foodstuff in small amounts to perform technological functions, namely colour, sweetness or to extend shelf life. In the European Union an E number identifies all food additives. According to the technological functions twenty-five categories of food additives have been defined....

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... use of antibiotics in food preservation is problematic since it can lead to the development of resistant microorganisms, with the consequent negative effects that this implies in its therapeutic application. Antibiotics nisin (E234) and pimaricin (natamycin -E235) have been used as food preservatives (Table 7; Fig. ...

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... In addition, the high frequency of alert notifications for herbs and spices and cereals, and bakery products suggests that these categories may be particularly prone to issues related to food additives and flavourings. In view of the situation in the rest of the countries around the world, it is somewhat similar, as many authors in many different countries were interested in assessing the risks associated with the excessive presence of food additives in vegetables and fruits (Carlos et al., 2019;Mischek & Krapfenbauer-Cermak, 2012;Sebaei & Refai, 2021;Zhang et al., 2014) that in addition to recent worldwide systematic reviews represented thousands of articles concerning such food additive contaminants in fruits and vegetables (Abdulmumeen et al., 2012;Hosseini et al., 2023;Silva & Lidon, 2016). ...
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... other hand, chemical preservation involves the incorporation of preservatives into food. Preservatives are intentionally added to food items to hinder or postpone microbial, enzymatic, or chemical alterations that can lead to nutrient degradation [7]. Common antimicrobial preservatives in the food industry include sodium and potassium salts of benzoic acid and sorbic acid. ...
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... When used in excess, it might cause negative effects such skin rashes and itching, breathing problems, sneezing, or stomach issues (Silva and Lidon., 2016). M. M. Silva and F. Lidon, 2016. ...
... When used in excess, it might cause negative effects such skin rashes and itching, breathing problems, sneezing, or stomach issues (Silva and Lidon., 2016). M. M. Silva and F. Lidon, 2016. Certain food preservatives are classi ed as carcinogens or cancer-causing agents due to their hazardous effects on human health. ...
... 2.11. Cytotoxicity assay: (30), odor (30), color (20), texture (20), acceptability (score 100). ...
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... Similarly, evidences for excessive sodium benzoate causing urticaria have been provided since 1973 [4,[8][9][10][11]. Benzoic acid may produce allergic reactions [12], and its sodium salt is claimed to inhibit certain enzyme activities [13] related to neurotoxic effects and fetal abnormalities [14]. ...
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