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4: Myelination allows saltatory conduction Top: Schematic demonstrating the propagation of an action potential along a myelinated (top) and unmyelinated (bottom) axon via saltatory conduction and continuous conduction respectively. Bottom: Graph from Waxman (1980) demonstrating the theoretical relationship between conduction velocity and diameter for myelinated (dashed line) and unmyelinated (solid line) axons. Myelinated axons exhibit a linear relationship between velocity and fiber diameter. Note how myelination only exerts a functional advantage to an axon over the size of approximately 0.2µm.
Source publication
Activity-mediated myelination, the adjustment of myelin morphology in response to
neuronal activity, has been proposed as a novel mechanism of central nervous system
(CNS) plasticity. As a key regulator of conduction velocity, adaptations in myelin structure
have the potential to exert spatiotemporal control over action potentials across
neurons of...
Contexts in source publication
Context 1
... the repository of tail tracking data, I extracted data for relevant tail parameters during OMRs and compared them across genotypes. Computed values for a range of tail parameters were remarkably similar between genotypes (Figure 4.14) suggesting that this prediction was not true. In summary, optomotor behaviour was remarkably preserved in Myrf -/-mutants despite widespread defects in CNS myelination. . ...
Context 2
... to the subtleties in the distribution changes and the non-parametric nature of the data, I was not surprised that no statistical differences were observed when parameters were plotted as an average per fish (Appendix 2, Figure 5.14). However, it is interesting that Myrf -/-mutant values are consistently higher than those of wild types, with close similarity to heterozygous siblings across the majority of parameters assessed. ...
