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Medical science still faces difficulties in developing side-effect-free medications for diabetes management. This has increased the need for safe and effective natural remedies that may lower blood sugar levels. The purpose of this study is to determine whether or not an ethanolic extract of Nyctanthes arbortristis Linn. leaves reduces blood sugar...
Citations
... icorandil in the dose of 40µg/kg body weight produces hyperglycemia up to 2-3 hrs. Insulin secretion from β cells of pancreas is related to inhibition of ATP sensitive K + channel , causing depolarization of cells of pancreatic islets which subsequently causes increase in intracellular Ca +2 concentration resulting release of insulin by exocytosis (Ahmed. 2006) . ATP sensitive K + channels that couple metabolism with membrane potential. An increase in local ATP, ADP ratio closes the channels, this reduces K + efflux & therefore tends to depolarize the cell membrane. The K + ATP channel that are regulated by SUR are the Kir 6.2 channels. There are three main SUR subtypes, Kir 6.2 SUR 1 is expre ...
... It has been found that hyperglycemia is one of the commonest side effects of potassium channel opener like diazoxide due to inhibition of insulin release. 9 The mean blood glucose level of different groups was compared and it was found that in glibenclamide group the mean blood glucose level significantly decreased with the treatment days. At day 0 the level of glucose was 279.40±9.32 and on day 28 it was 132.80±12.93, ...
... It indicates that the rats responded with glibenclamide treatment. The same findings were also reported by Ahmed SM and Meraj et al. 9,10 In nicorandil group the blood glucose level increased as the time progressed. Up to day 3 of treatment, no significant difference was observed but after day 5 onward a significant difference was observed (273.80±10.82 ...
... There in vivo data showed that 4 weeks of oral treatment with nicorandil to STZ-DM rats resulted in decreased blood glucose levels, retained plasma insulin concentrations, preservation of islet b-cells, and prevention of body weight loss compared with rats in the STZDM group that did not receive nicorandil treatment. 9,12 Thus because of pharmacokinetic and pharmacodynamics variations between animal and human species further studies are required to substantiate these results in diabetic ...
ABSTRACT
Background: Diabetes increases the risk of macrovascular complications and is often associated with angina in patient. Currently nicorandil, a potassium channel opener is being frequently used for the prevention and long-term treatment of angina pectoris. Glibenclamide exerts its antidiabetic action by closing the ATP sensitive potassium channels. Simultaneous use of nicorandil may antagonizes this action and may worsens the existing diabetes. To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide.
Methods: Albino rats, weighing 150-200gm of male sex were used for the study. Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. Animal with Fasting Blood Sugar level between 250-300g/dl was selected for study and they were divided into 4 groups of 5 animals each. Group I- serving as control received 0.5ml normal saline orally for 28 days. Group II was given glibenclamide (0.5mg/kg body wt) for 28 days. Group III was treated orally with nicorandil (0.3mg/kg body wt) for 28 days. Group IV was given glibenclamide (0.5mg/kg) and nicorandil (0.3mg/kg) for 28 days. Fasting Blood Sugar level was recorded in all rats on 1st,3rd,7th,14th,21st and 28th day of the treatments.
Results: results showed that glibenclamide significantly reduce blood sugar level (p <0.05) Wherase nicorandil showed rise in blood glucose level (p <0.05) While the combination (glibenclamide + nicorandil) showed rise in blood glucose (p <0.05) overall.
Conclusions: Nicorandil worsen the existing diabetes and to be avoided or replaced with alternative drug in case of diabetes being treated with sulfonyl urease group of drugs.
Keywords: Alloxan, Glibenclamide, Nicorandil, Sulfonylureas
... Such diabetogenic potential of nicorandil on chronic administration was observed in prescription-event monitoring. This finding is in conformity with the observation made by Ahmed et al, [11] who concluded that "nicorandil when added to glibenclamide (a sulfonylurea) in alloxan induced diabetic rats, worsened diabetes by antagonizing the hypoglycemic effect of glibenclamide. This is probably due to blockade of potassium channel closing action of glibenclamide by nicorandil on ATP sensitive K+ channels on the surface of beta cells of pancreas." ...
Many cells are equipped with so called potassium (K +) channels which have an important role in maintaining transmembrane potential. Nicorandil being a K + channel activator (primary mechanism) causes hyperpolarization of membrane potential of vascular endothelial cells leading to vasodilation. Earlier studies suggest that besides vasodilation this drug could alter physiological blood glucose homeostasis. The purpose of the present study is to evaluate the acute and chronic effect of Nicorandil (graded doses) on fasting and postprandial blood glucose level in albino rabbits (n=30). For this study, the blood glucose levels were estimated before and after intraperitoneal (IP) administration of nicorandil to see its effect. In our study, we observed no significant changes in blood glucose level in acute administration (single dose) even at higher doses 512 mcg/kg body weight (p > 0.1). Although we observed no significant changes in fasting glucose levels, there was significant rise in postprandial levels during chronic administration (for 15 days) p < 0.05.
