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Morphological traits of hereditary non–polyposis colorectal cancer. 1A, border showing trend to expanding growth, haematoxylin–eosin (HE), original magnification (OM) x100; 1B, mucinous component, HE, OM x100; 1C, high cancer grade, HE, OM x400; undifferentiated solid pattern, cytokeratin AE1/AE3, immunoperoxidase (IP), OM x100; 1E (inset), more marked host response in the form of high number of intratumoural lymphocytes within solid cancer, HE, OM x400; 1F, lack of MSH2 protein in hereditary colorectal cancer cells in contrast to benign cells, IP, MSH2 protein, OM x100; 1G, lack of MSH6 protein in hereditary colorectal cancer cells, IP, MSH6 protein, OM x100; 1H (inset), positive control for MSH6 protein visualisation: expression of MSH6 protein in sporadic colorectal cancer, IP, MSH6 protein, OM x400
Source publication
The Concept, Diagnostics, Surgical Prevention and Treatment of Hereditary Colorectal Cancer in Nowadays Medicine
Colorectal cancer is a frequent cause of oncological morbidity and mortality. It is the second most common cancer in Europe (13.0%) almost matching the frequency of lung cancer, the most widespread malignancy (13.2%). In European Union c...
Context in source publication
Context 1
... lifetime risk of colorectal cancer in HNPCC-related mutation carriers is 80%, and the average age of diagnosis is 44 years (18). HNPCC-related colorectal cancer is characterised by more frequent occurrence in the right side of colon (18), certain histological features (Figure 1), high rate of microsatellite instability, improved survival but high risk of metachronous colorectal cancer. The rate of right colonic tumours is 60-80% in HNPCC vs. 23-32% of sporadic colorectal cancers (18). ...
Citations
Lynch syndrome (LS), a hereditary cancer syndrome, accounts for approximately 3% of colorectal cancers (CRC). Positive health behaviors and surveillance are preventive strategies, but research on whether recommended behavioral guidelines are followed by individuals with LS is limited. Additional health education and promotion could be beneficial to the improved survivorship of CRC survivors. Explore health and lifestyle behaviors in CRC survivors with and without LS. We conducted a case-control study of CRC survivors with and without LS using a mailed questionnaire. Recruitment was conducted via patient registries at The University of Texas MD Anderson Cancer Center (cases n = 33; controls n = 75) and through social media (cases n = 42). CRC survivors with and without LS in our study had substantially lower smoking prevalence (5.5% and 2.7%) compared to national prevalence (18.0%). However, they had higher levels of alcohol consumption (36.8% and 10.3% for male and female LS survivors, respectively, and 35.8% and 22.0% for male and female sporadic survivors, respectively) compared to national prevalence of 13.88% for males and 6.02% for females. Both groups of CRC survivors participate in negative health behaviors that impact survivorship. More research is needed to examine the relationship between personal engagement in preventive behaviors and patient–provider relationships to improve health behaviors and explore strategies for intervention. Additionally, better health education and lifestyle change recommendations would promote and reinforce positive health outcomes in the CRC population and especially in LS survivors.
