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Despite advances in biomedical technology, many communities and local people are still dependent on natural and herbal medications. A large number of different ethnic groups like the Tharu, Kani, Garo and other local inhabitants thrive in the Indian subcontinent and other parts of the world. These indigenous people traditionally use Mallotus philip...
Contexts in source publication
Context 1
... are usually terminal and fruits are trilobed dehiscent capsules. Fruits bear red coloured glandular hairs yielding a red powder known as 'Kamala' (Sierra et al. 2005) (Figure 1). ...
Context 2
... are usually terminal and fruits are trilobed dehiscent capsules. Fruits bear red coloured glandular hairs yielding a red powder known as 'Kamala' (Sierra et al. 2005) (Figure 1). ...
Citations
... The fruits of the plant are most common element of various Ayurvedic and Unani formulations. [1] It has wide array of therapeutic applicability such as Dermatological disorders, [2] Digestive disorders, [3,4] Helminthic disorders, [5,6] Inflammatory disorders, [7,8] Microbial infections, [9,10] Psychological disorders, [11] Reproductive disorders, [12] Respiratory disorders, [13] in vitro cytotoxicity, [14] etc. ...
... To achieve best chromatographic performance numerical optimization technique by desirability approach was used. The desirability function ranges from undesired response (0) to fully desired response (1). The desirability value close to 1 dictate global optimization of selected combination of different criteria. ...
Rottlerin, a natural polyphenolic ketone is a major constituent of Mallotus
philippensis (Lam.) Mull. Arg. plant. Although, less explored it has diverse array of therapeutic
applications. Objectives: The current work aimed to develop novel, simple, speedy, accurate,
potent High Performance Thin Layer Chromatography Method (HPTLC) to separate, and quantify
rottlerin from the herbal topical patch In-House formulation. Materials and Methods: This was
the foremost attempt to develop and validate HPTLC method using Analytical Quality by design
(AQbD) approach. Box Behnken design (BBD) coupled with response surface methodology
approach was followed for the systematic optimization. The end results of toluene content,
chamber conditioning time, and solvent front on Rf
value of rottlerin was studied. The optimised
method was validated as per ICH guidelines. Results: For HPTLC, stationary phase used was
aluminium plates 60F254 coated with silica gel as. AQbD optimised conditions were mobile phase
proportion namely toluene: ethyl acetate: methanol: ammonia (5:4:2:0.2), development distance
80 mm, band width 6mm, and chamber saturation time 10 min. The method generated well
resolved and compact bands at Rf
of 0.41±0.05. The developed method exhibited high accuracy,
precision, robustness, and recovery. The quantity of Rottlerin in developed herbal patch was
found to be 134.8 ng/band. Conclusion: In a nutshell, the present study undeniably vouches for
a QbD based method development approach for Rottlerin and can be extrapolated to estimate it
in other herbal extracts, or marketed formulations.
Keywords: Rottlerin, Analytical Quality by design (AQbD), HPTLC, Mallotus philippensis (Lam.)
Mull. Arg., Topical patc
... The fruits of the plant are most common element of various Ayurvedic and Unani formulations. [1] It has wide array of therapeutic applicability such as Dermatological disorders, [2] Digestive disorders, [3,4] Helminthic disorders, [5,6] Inflammatory disorders, [7,8] Microbial infections, [9,10] Psychological disorders, [11] Reproductive disorders, [12] Respiratory disorders, [13] in vitro cytotoxicity, [14] etc. ...
... To achieve best chromatographic performance numerical optimization technique by desirability approach was used. The desirability function ranges from undesired response (0) to fully desired response (1). The desirability value close to 1 dictate global optimization of selected combination of different criteria. ...
... These people are mainly depending upon plants to combat their daily needs (Bhatti et al., 2016Kumar et al., 2022). According to World Health Organization more than 80% of world's population or 4.3 billion people of developing countries mainly rely upon the plant based medicines for curing different diseases (Bhatti et al., 2016;Kant and Pandey, 2022;Abhishek et al.,2020). ...
An ethno-botanical survey was conducted to identify the medicinal plants in Hamirpur District, Himachal Pradesh, concerned the treatment of fever. The informants of rural area were intervened through semi-structured questionnaire. 1366 citations were made for 73 plant species belonging to 31 families for the treatment of fever including malaria, typhoid, Dengue, Chikungunya and cold fever. Among them most of the plants were herbs (46%) followed by shrubs (29%), trees (20%), climbers (5%). In the study, families with maximum number of species used in the treatment of fever comprises, Lamiaceae (12 Species), Malvaceae (6species), Fabaceae, Solanaceae and Acanthaceae (5 species), Amaranthaceae, Asteraceae (4species), Menispermaceae, Rutaceae (3 species), Anacardiaceae, Capparaceae, Meliaceae, and Oxalidaceae (2 species). The most common mode of administration is Decoction followed by Powder and others. On the basis of Use reports (citations) and Citation Frequency, most important and frequently used species are Tinospora
... These underutilised wild plants have other multipurpose uses ranging from food and medicinal to economic benefits (Ulian et al. 2020, Hussain et al., 2022. Good nutrition is associated with health benefits, and many WEPs are also traditionally used for medicinal purposes (Kumar et al. 2020). The bioactive secondary compounds in the WEPs promote good health and protect against many diseases (Nirmala et al. 2014;Santosh et al. 2019). ...
Wild edible plants have gained attention due to growing concerns for global food security. Nutrient contents are frequently determined for wild edible plants identified from ethnobotanical surveys.In this article, we conducted an ethnobotanical survey at the study site and collected twenty-one wild plants for evaluating their relative nutrient indices. Our results suggested that the tubers of Colocasia esculenta had the highest macronutrients, fruits of Spondias pinnata had high vitamins, the leaves of Colocasia esculenta and Chenopodium giganteum had high dietary fibres, and leaves of Digera muricatawere rich in minerals. Thus, these plants can offer a basis for developing dietary supplements and nutraceuticals on a commercial scale, which may help in achievingthe sustainable development goal of zero hunger.
... The plant is known for its different pharmacological activities such as antimicrobial, antiviral, immunomodulatory, cytotoxic, purgative, anthelmintic, carminative, anti-inflammatory, antioxidant, antidiabetic, antidiarrheal, analgesic and antifertility activity (Tripathi and Chaudhary 2017). The plant is useful in treatment of respiratory, digestive, psychological, excretory, reproductive, skeletal and skin disorders (Kumar et al. 2020). The large number of ethnic groups in Indian subcontinent and all over the world use Mallotus philippensis (Lam.) ...
... Arg. for medicinal, ritual and economic purposes. Among all other plant parts, fruits are the most exclusively used part due to its wide array of therapeutic activities (Kumar et al. 2020). The fruits are the treatment of choice for dermatological disorders especially for non-healing and infected wounds. ...
The healing of wound is a tightly-regulated cascade of events, involving interplay of enormous factors. Now a days, pain alleviation and faster wound healing have attracted considerable attention. Several natural compounds have played crucial role in this intriguing process. The present study deals with five selected molecules from the plant Mallotus philippensis (Lam.) Mull. Arg. targeting the eight essential proteins involved in the wound healing and inflammatory process. Considering that various phytoconstituents of medicinal plant can simultaneously interacts with multiple targets, in current work multiligand and multitarget approach was employed instead of traditional one ligand-multitarget approach. Docking studies were performed using AutoDock Vina and molecular dynamics was performed using GROMACS 2019. The current study revealed the potential interactions of five selected constituents with multiple chronic wound healing targets. The wound healing effect of Mallotus philippensis (Lam.) Mull. Arg. fruits may be due to combined effect of all these compounds. Effective interactions with the amino acid residues present in the active site of some of the essential proteins involved in the wound healing process also suggests possible mechanism in the wound healing process. The current work thus provides a meaningful insight that Mallotus philippensis (Lam.) Mull. Arg. fruits could be used as potential candidate for faster healing of wound. Also, in silico studies depicting interaction with the targets and receptors provide a meaningful insight that this plant would be used as potential candidate for new drug development.
Background: Plants play an essential role in every rural society's cultural and religious ceremonies. The focus of the study was to document the use of plants by the indigenous communities of sub-Himalayan Tract, Uttarakhand in magico-religious practices. Method: Information was extracted from eighty informants (50 men; 30 women) between 25 to 75 years of age. A semi-structured questionnaire, interviews, and participatory observations were made to collect data from the informants to meet the study's requirements. Results: The present study revealed 34 plants belonging to 31 genera and 25 families for the magico-religious practices. Fruits and whole plants are mainly used to conduct various social and religious practices, such as offerings in religious ceremonies. Herbs (59%) were the dominant forms, and wastelands (48%) were the dominant source of magico-religious plants. High Informant Consensus Factor (Fic) was recorded for the plants used in the sacred and religious rites (SAR) category. Species such as Datura stramonium, Ocimum tenuiflorum, Ficus benghalensis, Cynodon dactylon, Achyranthes aspera, and Calotropis procera were culturally most important based on cultural index value. Conclusion: The plant species play a vital role in practicing the religion and culture among the studied communities. Therefore, it is suggested that the indigenous communities of the sub-Himalayan region be monitored and contacted regularly about their beliefs. They must be informed and made aware of the importance of plant diversity and the significant loss that will occur if it is lost. © 2022, Ilia State University, Institute of Botany, Department of Ethnobotany. All rights reserved.
