Morphological changes during necrosis and apoptosis. 

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... genes in the execution phase of cell death were found to have homologues in mammalian cells, i.e. apoptosis is an evolutionary conserved mechanism (Sulston & Horvitz, 1977). Apoptosis is a strictly coordinated event where cells decompose into small membrane-enclosed vesicles called apoptotic bodies, readily phagocytosed avoiding inflammation (Fig. 8). Due to rapid phagocytosis of apoptotic cell bodies this type of cell death is often hard to observe in vivo. Another hallmark of apoptosis is chromatin condensation and DNA fragmentation (Wyllie et al., 1984, Oberhammer et al., 1993. Further, apoptotic cells lose the phospholipid asymmetry in their plasma membrane, manifested by ...