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Molecular mechanism of HSCs mobilization. G-CSF triggers HSC mobilization thorough two main routes. One rout is mediated by proteases releasing from myeloid cells and another routes is mediated by CXCL12/SDF-1 expression attenuation in osteoblast cells
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Introduction: Today, autologous peripheral blood stem cell transplantation is considered as a substitute procedure for Autologous bone marrow transplantation. Treatment with G-CSF mobilizes CD34+ HSCs from bone marrow into peripheral blood and could be used as a marker for hematopoietic stem cells mobilization and subsequent apheresis. Methods: In...
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... one part of mobilization is mediated by pro- teases that cleave interaction among the expressed adhesion molecules on stem cells and their ligands surface in bone marrow stroma and another part is mediated by non-proteo- lytic mechanism regulating molecular expression of stroma cell-derived factor 1 (SDF-1) at mRNA level (25) (Figure 1). ...
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