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Molecular Interaction of Cyclooxygenase-2 with the identified lead AI 1003. Green colour represents the hydrogen interaction between the target and ligand molecule. Active site residues involved in the interation are represented by Black colour Hydrogen bond interaction are shown between NeH/O of compound AI 1003 with the amino acid ARG 120 at the distance of 2.12(Å) and 2.79 (Å).
Source publication
Abutilon indicum is a plant that belongs to the Malvaceae family, which is distributed throughout a number of tropical and subtropical areas and has been used for various disorders in traditional and folk medicine. The various medicinal applications of this plant include anti-inflammatory, antioxidant, demulcent, aphrodisiac, laxative, diuretic, pu...
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![Figure 1: Area under Mesta & Kenaf in Bangladesh (Source: Islam [3]).](profile/Md-Islam-350/publication/333654088/figure/fig1/AS:767161928798213@1559917065520/Area-under-Mesta-Kenaf-in-Bangladesh-Source-Islam-3_Q320.jpg)
![Figure 2: Taxonomy (Islam M.M. [3]).](profile/Md-Islam-350/publication/333654088/figure/fig2/AS:767161928794113@1559917065555/Taxonomy-Islam-MM-3_Q320.jpg)
Roselle/Mesta plant (Hibiscus sabdariffa L. Linne Malvaceae) was selected for its being large concentration point in relation to research advances on food and medicinal values. Data were collected from different print media like different annual reports and national and international journals during the year 2018 at Agronomy Division, Bangladesh Ju...
Citations
... Herbal remedies such as roots, stems, leaves, flowers, and fruit contain some flavonoids, phenolic compounds, steroid, alkaloids, tannins, saponins, and glycosides that may be useful in treating inflammatory diseases, cardiovascular diseases, diabetes, muscular weakness, heart disease, bleeding disorders, and paralysis [18][19][20]. The A. indicum herb is currently accepted for folk and traditional medicine as the main source of diabetes; however, the cytotoxicity of plant extract has not been investigated for antidiabetic properties [21,22]. Therefore, the main aim of this research work was to extract the crude A. indicum plant leaf extract and that could use to improve the responsiveness of adipocytes and lipolysis activity and potentially used as adjuvant in the treatment of diabetes. ...
Abutilon indicum (L) is an Indian traditional plant used for the treatment of diabetes and heart diseases. The present study is to evaluate the functional of A. indicum leaf extract as insulin like character to inhibit lipolysis and stimulates Adipogenesis activity. The ability of the A. indicum leaf extract in anti-obesity effect of Adipogenesis, lipolysis and cholesterol esterase functions can be predicted by using 3T3-L1 adipocyte cell lines. Substances were isolated from A. indicum leaves and the double filtered crude sample were used for Adipogenesis, lipolysis and cholesterol esterase activity using 3T3-L1 adipocytes at different concentrations. We used differential media-I, differential media-II and maintenance media (MM1) at concentrations of 20, 40, 60, 80, 100, 200 and 400 µg/mL respectively. In addition to the extract, there is a significance increase in glycerol release (p < 0.001) compared with crude and reference compounds. Cholesterol esterase activity predicts the IC50 = 27.11 µg/mL of orlistat positive control compare with IC50 = 8.158 µg/mL of crude extract. Based on the observation, A. indicum leaf extract can promotes lipolysis and differentiated adipocytes. It is potentially used as adjuvant in the treatment of Type 2 diabetes.
... The phytochemicals present in Abutilon indicum are alkaloids, flavonoids, saponins and essential oil [14]. The seeds are used to treat coughs and the bark is used as an anthelmintic [15,16]. The leaves are used for treating tender gums, bleeding piles and toothache. ...
Tecoma stans is a flowering plant belonging to the family Bignoniaceae. It is the floral emblem of the Bahamas. Abutilon indicum belongs to the family Malvaceae. It is also called Indian Mallow. Tecoma stans and Abutilon indicumhave antimicrobial activity and can be used in producing antibiotics. There is an urgent need to produce new antibiotics as there is an increase in the development of pathogen resistant drugs. The aim of this study was to compare the antimicrobial activity of ethanolic extract of Tecoma stansand Abutilonindicum leaves. E.faecalis bacteria were maintained in nutrient agar slopes. The powder of the two herbs, were subjected to extraction by Soxhlet extractor and was concentrated to dry residue by Agar well diffusion method. The nutrient broth was inoculated with bacterial strains. The culture was adjusted to 0.5McFarland turbidity standard. Lawn culture was done in Muller-Hinton agar plate and then the plates were dried. A 6 mm diameter well is bored for different concentrations. The extracts were introduced into the well and allowed to stand for 24 hrs. The antibacterial activity was determined by measuring the zone of inhibition. The present finding on the antimicrobial potential of Abutilon indicum and Tecoma stands showed that the two plants have growth inhibitory activity against oral pathogen E. faecalis. Abutilon indicum has a zone of inhibition greater than Tecoma stans. Abutilon indicum exhibited better activity compared to Tecoma stans.
... (Xiao et al.,2012). The extract is also high in antioxidants, further limiting cancer cell development (Sasikala and Meena, 2018). An previous research showed the significance of the AKT/mTOR pathway in reducing BC cell survival and proliferation by using another naturally occurring route (Memmott and Dennis, 2010). ...
Objective
Abutilon indicum is a medicinal plant belonging to the Malvaceae family. The current study has been developed to detect Abutilon indicum bio-activity to produce an adequate drug design for cancer.
Methods
The objective of this work is to perform molecular docking and dynamics as well as inhibitors and cancer cell line studies of Abutilon indicum would be essentially effective to use current strong medicines from oncology therapies.
Results
By Docking best finding binding energy -12.02kcal/mol (ARG310, ASP323, SER291, THR358, GLU293) amino acid has been found to be immersed in the formation of the hydrogen interaction. This finding also indicates that a range of compounds are ADMET positive drug molecules in cancer studies. Network pharmacology showed that the signal rule ERG, PTEN, NKX31, AR, ETV4, STAT3, PTPN11, CBL, KRAS, EREG, STAT3, GRB2, HRAS, and SHC1, and the axis of DRD2. Molecular simulation trajectories show that RMS deviation profiles were relatively stable during the simulation and it indicated the orientations were created by the docking studies. In cell lines MCF-7, the active compound R-N-1'-methoxycarbonyl-2'-phenylethyl-4-hydroxy benzamide has anticancer inhibitory 76.56% at 100μg/mL. The ASP323 interaction of EGFR inhibitors interaction molecules were derived that can be successfully used to explain the cancer activities.
Conclusion
The results of pharmacodynamic and toxicity for natural organic derived compound and its active results epidermal growth factor receptor for identifying novel drugs for the treatment confirms compound moderate to a good cancer drug.
... Although the pharmacological properties are important factors for drug discovery, the PK aspects are the main responsible to predict if the drug will advance its effectiveness and safety aiming the therapeutic success [25]. The in silico studies to predict Absorption Distribution Metabolism Excretion and Toxicity (ADMET) properties help in the analysis of novel substances to avoid spending time on candidates that would be toxic or metabolized by body enzymes into an inactive or unable form to cross cell membranes and thus work with only promising compounds [26,27]. Therefore, using in silico techniques and validation of the predicted potential by ex vivo experiments, this study aimed to explore the pharmacological and PK aspects of NDIBP as a candidate for a new NO donor. ...
Objective: This study aimed to describe the synthesis and biological/pharmacokinetic potential of the 1,3-diisobutoxypropan-2-yl nitrate (NDIBP) using in silico and ex vivo approaches. Methods: The compound was characterized by Fourier-transform infrared spectroscopy and 1H and 13C- nuclear magnetic resonance spectra. NDIBP biological activity spectrum was obtained by Prediction of Activity Spectra for Substances (PASS). The pharmacological effect was validated in ex vivo studies using mesenteric artery. Drug-like properties and Absorption Distribution Metabolism Excretion and Toxicity (ADMET) studies were carried out by pkCSM (Predicting Small-Molecule Pharmacokinetic Properties Using Graph-Based Signatures) software. Results: PASS prediction indicated NDIBP as nitric oxide (NO) donor with vasodilator effect. Ex vivo studies validated PASS analysis and showed the NDIBP vasorelaxant activity in mesenteric arteries. Physicochemical parameters and ADMET prediction suggested that NDIBP is a drug-like molecule with a good theoretical oral bioavailability, good absorption in the gastrointestinal tract, and a low distribution in the tissues. Conclusion: All the data indicated that NDIBP possesses biological activities and drug-like properties to be considered as a vasorelaxant agent and a good candidate for further investigation in the treatment of arterial hypertension and drug development studies.
... Abutilon indicum fruit pentadecanoic acid 14-methylmethyl ester anti-inflammatory ( Sasikala and Meena, 2018 ) 3 ...
Globally, traditional herbal medicines have played a vital role in health systems, and are used to treat various acute and chronic conditions without or minimal toxic effect. Herbal plants are often used as a natural remedy to cure various health problems including tuberculosis, cancer, diabetes mellitus, heart diseases, wound healing, asthma, pharyngitis, hypertension etc. Plants rich in bioactive phytomedicine compounds such as alkaloids, flavonoids, tannins and polyphenols have been used to cure illnesses because of their various pharmacological properties. India is always known to be rich depository of medicinal plants and various forms of herbal medicine practices are considered as “living tradition”. However, there is no collective report on the significant Indian medicinal plants and their current progress in medicinal plant research. Hence, the prime focus of this review is to identify and report the majorly used Indian medicinal plants that have grown in India and neighboring countries based on a complete research survey of local and international research articles. The review mainly summarizes the prominent Indian medicinal plants, their extract and its corresponding pharmacological properties such as anti-microbial, antioxidant, anti-diabetic, and anti-cancer etc. The significance of this review is aimed to provide a detailed and collective scientific evaluation of the key phytocompounds and its pharmacological action for the possible development of new ethnomedicine in the future.
a native traditional plant commonly known as Indian Mallow, is a versatile plant species that brings enormous amounts of medicinal uses from the history of traditional culture. This review emphasizes the current body of knowledge surrounding the effects of , highlighting its potential therapeutic application. The plant is well renowned for its diverse phytochemical composition, including alkaloids, flavonoids, and polysaccharides, which contribute to its wide-ranging biological activity. It has been discovered through research that Abutilon indicum extracts possess noteworthy pharmacological effects, including anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective properties. In addition to its immunomodulatory effects, larvicidal, anti-convulsant, neuroprotective, and cognitive-enhancing capacities have gained attention in recent years and serve as natural alternatives to available allopathic medicine.
The focus of the review revolves around various noteworthy pharmacological effects of , including its anti-inflammatory, anti-microbial, anti-oxidant, and anti-convulsant properties. Furthermore, the examination of the plant extracts' phytochemical composition is also emphasized.
Those activities were discussed and reported with standard methods and compared with the available standard drugs. Overall, this comprehensive review provides valuable insights into the pharmacological effects of , underscoring its potential as a source of novel therapeutic agents and paving the way for future research and development.
Natural product screening in plants has always been a difficult task due to the complex nature of the plant material and diverse structures of the compounds present in them. Among them, flavonoids are important and diverse class of plant secondary metabolites with numerous medicinal activities. The present study focuses on the development of a high-resolution tandem mass spectral library for the rapid and authentic identification of common flavonoids. A total of forty flavonoid standards belong to class flavones, isoflavones, flavanones, flavanols and anthocyanins were pooled into three solutions applying logP-based strategy. The flavonoids were analyzed using LC-QTOF-MS high-resolution mass spectrometer with optimization of different instrumental parameters to achieve good sensitivity. The library was built by incorporating names, molecular formulae, exact masses, and MS, and MS/MS spectra of analyzed flavonoids using Bruker Library Editor tool. The fragmentation pattern observed for the standard compounds were compared to the fragments reported in the literature. To assess the practical implications, an extract of tea sample was analyzed and screened using the developed library, which resulted in the identification of three common flavonoids based on their HR-ESI-MS/MS spectral features. The established LC-HR-MS/MS method can be used for the targeted identification of flavonoids in complex samples like food material from different botanical families.
The present study was performed to find out the structural similarity of hydroalcoholic extract of abutilon indicum and standard non-steroidal anti-inflammatory drugs (NSAIDs) using various analytical and chromatography techniques. The characterization was performed by fourier transform infrared spectrophotometer (FTIR), UV–Vis spectrophotometer, thin layer chromatography (TLC), and reverse-phase high phase liquid chromatography (RP-HPLC). Paracetamol and aceclofenac were used as standard NSAIDs. The FTIR peaks obtained for abutilon indicum were at wavenumber 2933.81, 2359.61, 1459.90, 762.73, 1640.09, 1559.74, and 3253.75 cm⁻¹ confirms the presence of aromatic acid, hydroxyl group, and carboxylic groups. In addition, the UV–Vis profile showed peaks at 274 nm and 244.5 nm for abutilon indicum in methanol and sodium hydroxide respectively. Further, the TLC method showed the retention factor (Rf) values at 0.38 and 0.36 for abutilon indicum which were almost similar to Rf values of paracetamol and aceclofenac. The peak and retention time from RP-HPLC for abutilon indicum showed the values at 3.640 and 2.603 that were in accordance with standard NSAIDs. Thus, this study can give an insight that abutilon indicum does contain structures similar to paracetamol and aceclofenac which are responsible for their analgesic activity.
