Figure 3 - uploaded by Iman Hewedi
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Mitotically-active leiomyoma with low Prune 2 expression; immuoperoxidase, original magnification ×200.
Source publication
The histologic classification of uterine smooth muscle tumors regarding their malignant potential is often challenging dilemma. Prune 2 has been reported to have a diagnostic utility in differentiating leiomyosarcomas from gastrointestinal stromal tumors. However, its diagnostic value in leiomyosarcoma versus other uterine smooth muscle tumors has...
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The unidentified presence of uterine smooth muscle malignancies poses a tremendous risk in women planning surgery for presumed benign leiomyomas. We sought to investigate whether preoperative FDG PET may be useful to identify leiomyosarcomas (LMS) and smooth muscle tumors of uncertain malignant potential (STUMP). Methods . We investigated patients...
Retro peritoneal smooth muscle tumors of uncertain malignant potential (STUMP) are rare and often misdiagnosed as leiomyosarcoma. We hereby report the case of a retroperitoneal STUMP diagnosed on a surgical specimen in a 44-year-old woman without any history of disease.
Background
Uterine leiomyosarcoma (uLMS) may show loss of expression of B-cell lymphoma-2 (Bcl-2) protein. It has been suggested that Bcl-2 loss may both be a diagnostic marker and an unfavorable prognostic marker in uLMS.
Objective
To define the diagnostic and prognostic value of Bcl-2 loss in uLMS through a systematic review and meta-analysis....
Information about the clinical behaviour and risk factors of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential
(STUMPs) is extremely limited. Most of the patients with STUMP are at reproductive age. Postmenopausal bleeding (PMB) can oc�cur about 10% of patients after menopause. An uterine leiomyosarcoma may be the cause of PMB in some...
We aimed to develop an artificial intelligence (AI) diagnosis system for uterine smooth muscle tumors (UMTs) by using deep learning. We analyzed the morphological features of UMTs on whole-slide images (233, 108, and 30 digital slides of leiomyosarcomas, leiomyomas, and smooth muscle tumors of uncertain malignant potential stained with hematoxylin...
