Figure 1 - uploaded by Emmanuel Nna
Content may be subject to copyright.
5 Mitosis in animal cells. During interphase (G1-S-G2 phases of cell cycle) DNA is doubled in preparation for cell division. During the prophase, the nuclear envelope breaks down and a spindle forms between the centrioles. https:/.../Katie+Mitosis+and+Meiosis+Lab.

5 Mitosis in animal cells. During interphase (G1-S-G2 phases of cell cycle) DNA is doubled in preparation for cell division. During the prophase, the nuclear envelope breaks down and a spindle forms between the centrioles. https:/.../Katie+Mitosis+and+Meiosis+Lab.

Source publication
Thesis
Full-text available
In the UK, more than 30 000 men are diagnosed annually with prostate cancer (PCa) and about 10 000 men die from it each year. Although several molecular markers have been associated with prostate cancer development and/ or progression, only few of them are used in diagnostic pathology. The current standard tests include serum PSA test, digital rect...

Similar publications

Article
Full-text available
The ubiquitin-conjugating enzyme 2C (UBE2C) is the key component in the ubiquitin proteasome system (UPS) by partnering with the anaphase‑promoting complex (APC/C). A high UBE2C protein expression level has been reported in various types of human tumors. However, little is known about the precise mechanism by which UBE2C expression is downregulated...
Article
Analog-sensitive (AS) kinases contain large to small mutations in the gatekeeper position rendering them susceptible to inhibition with bulky analogs of pyrazolopyrimidine-based Src kinase inhibitors (e.g. PP1). This ‘bump-hole’ method has been utilized for at least 85 of ~520 kinases, but many kinases are intolerant to this approach. To expand the...
Article
Full-text available
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972...
Article
Full-text available
Background: Epithelial to mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood, which has hindered the development of effective t...
Article
Full-text available
Background The newly synthesized Aurora-A kinase inhibitor XY-4 is a potential anti-cancer agent, but its hydrophobicity and limited efficiency restrict further application. Nanotechnology based combined therapy provides an optimized strategy for solving these issues. Methods In this study, the newly synthesized Aurora-A kinase inhibitor XY-4 and...