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Milestones in the history of psoriasis
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... chronic inflammation in psoriasis pathogenesis leads to a higher incidence of cardiovascular disease in patients. Moreover, psoriasis has been associated with comorbidities like psoriatic arthritis, metabolic syndrome and brain diseases, requiring interdisciplinary co-ordination between many specialists to provide optimized treatments [ Table 1 ...Similar publications
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... Skin lesions can cause burning and itching symptoms. [3] [4] Psoriasis is associated with several co-morbidities, including Psoriatic arthritis, Cardiovascular diseases, Metabolic syndrome, Depression and anxiety, Inflammatory bowel disease, Obesity, Diabetes. [5] Psoriasis, as a disease entity, is juxtaposed along with heart failure, cancer and obstructive pulmonary disease -diseases that most often lead to disability. ...
Introduction: Psoriasis is a systemic inflammatory disease with an immunological basis. The estimated number of people suffering from psoriasis is 60 million. Despite the large number of patients with this diagnosis, the question of which mechanisms are mainly responsible for its development has not yet been answered. One theory is that a change in the patient's psychological state acts as a trigger for the manifestation and worsening of the disease. Another unresolved issue is the relationship between sports and psoriasis. While some studies suggest exercise might worsen symptoms, others highlight potential benefits like improved quality of life. Aim of the study : The aim of our study is to present connection between mental state of patients and occurance of psoriasis. Additionally, the study aims to elucidate the potential benefits of integrating psychological interventions and physical activity into psoriasis management strategies, with the goal of improving patient outcomes and enhancing overall quality of life. Material and methods : We searched electronic databases, using keywords such as „Psoriasis”, „Depression” and „Psoriasis and sport ”. Conclusions : Psoriasis stands as a profound example of the intricate interplay between physical health and mental well-being. The findings presented in this paper underscore the importance of a holistic approach to psoriasis management, integrating dermatological, psychological, and physical interventions.
Psoriasis is an autoimmune chronic disorder that causes inflammation and a scaly epidermis. The exact pathogenesis of the disease is not known yet. According to the studies, psoriasis is considered an immune-mediated disease. Until now it is believed that genetic and environmental factors are responsible for the disease. There are many comorbidities associated with psoriasis which increases difficulties as patients in some cases get addicted to drugs, alcohol, and smoking which reduces their quality of life. The patient may face social ignorance or suicidal thoughts which may arise in the patient's mind. Due to the undefined trigger of the disease, the treatment is not fully established but by considering the severe impact of the disease researchers are focusing on novel approaches for successful treatment. which has succeeded to a large extent. Here we review pathogenesis, problems faced by psoriatic patients, the need for the development of new treatments over conventional therapies, and the history of psoriatic treatments. We thoroughly focus on emerging treatments like biologics, biosimilars, and small molecules which are now showing more efficacy and safety than conventional treatments. Also, this review article discusses novel approaches which are now in research such as drug repurposing, treatment by stimulation of the vagus nerve, regulation of microbiota, and autophagy for improving disease conditions.
