Figure - available from: Case Reports in Dentistry
This content is subject to copyright. Terms and conditions apply.
Source publication
Benign oropharyngeal tumors are far less common compared to malignant tumors. Oropharyngeal papilloma is present in adults. Squamous papillomas are exophytic masses of oral cavity. When they occur on the palate they are most often asymptomatic and benign. Pedunculated squamous papillomas usually arise from the soft palate, tonsil, or the epiglottis...
Similar publications
Background
This pilot study examined airway characteristics during upper endoscopy to determine who is at high risk for obstructive sleep apnea.
Methods
Patients undergoing routine upper endoscopy were divided into 2 groups according to the Berlin Questionnaire (high and low risk for sleep disordered breathing). Patients underwent routine upper en...
Prenatal ultrasound examination should take place between 18 and 20 week of gestation and is important for early detection of fetal anomalies such as the facial malformations. One important anatomic element is the palate that raises echographic technical difficulties such as the shadowing by facial bones and, especially, by the superior alveolar ri...
Snoring noise is generated by vibration of the soft tissues of the upper airway, principally those that form the back of the roof of the mouth (the soft palate) and its conical extension (the uvula). In addition to discord with bed partners, snorers are at much greater risk of obstructive sleep apnoea. This sleep-related breathing disorder is chara...
PurposeTo evaluate the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS), explore the structural changes in pharyngeal soft tissue underlying OSAHS development and analyze the correlation between hormone levels and pharyngeal soft tissue changes in patients with untreated acromegaly. Methods
Twenty-five patients with untreated acromega...
Citations
... A total of 76 pediatric subjects were diagnosed with oral HPV-related lesions, which were divided into 37 papillomas [17,20,21,23,25,[28][29][30][31]33,35,[40][41][42]45,46], 19 verrucae vulgaris cases [2,22,24,36], and 13 condyloma acuminata cases [2,26,27,32,34,37,38,43,44]. ...
... Macroscopic features were reported in 22 [2,17,20,25,26,[28][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45], while microscopic ones were reported in 20 studies [2,17,20,21,24,25,[28][29][30][31][32][33][34][35][37][38][39]41,42,44], respectively. ...
... Macroscopic features were reported in 22 [2,17,20,25,26,[28][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45], while microscopic ones were reported in 20 studies [2,17,20,21,24,25,[28][29][30][31][32][33][34][35][37][38][39]41,42,44], respectively. ...
Simple Summary
The present systematic review aimed to gain deeper insight into the epidemiology, clinical presentation, and histopathology of HPV-related benign and malignant lesions of the oral mucosa in pediatric patients to improve the multidisciplinary preventive and therapeutic management of oral and general healthcare. The emerging role of HPV in oral carcinogenesis in pediatric subjects, along with benign oral mucosal lesions and asymptomatic infections, brings HPV vaccination to the forefront specifically for this age group.
Abstract
The present systematic review aimed to assess the prevalence of oral HPV-related lesions, categorized as benign (verruca vulgaris “VV”, squamous cell papilloma “SP”, condyloma acuminata “CA”, and focal epithelial hyperplasia “FEH”) and malignant (oral squamous cell carcinoma “OSCC”), in descending order of occurrence in pediatric subjects (≤18 years of age). The secondary objectives were to evaluate the frequency and types of oral lesions described in relation to HPV genotypes and the HPV vaccine type (if any). The study protocol, compliant with the PRISMA statement, was registered at PROSPERO (CRD42022352268). Data from 60 studies, of which quality was assessed using the ROBINS-I tool, were independently extracted and synthesized. Along with seven poorly described benign HPV-related oral lesions that could not be categorized, a total of 146 HPV-related oral lesions, namely 47.26% (n = 69) VV, SP, and CA, 51.37% (n = 75) FEH, and 1.37% (n = 2) OSSC, were diagnosed in 153 pediatric subjects (M:F ratio = 1:1.4) with a mean age of lesion onset of 8.46 years. The viral genotypes detected were HPV-13 (30.61%), -6 (20.41%), -11 (16.33%), HPV-2 (12.24%), -32 (10.20%), -57 (6.12%), and -16 (4.08%). No HPV vaccination was reported in any case. Further studies should be conducted to evaluate the prevalence of HPV-related benign and malignant lesions and the potential role of HPV and associated vaccination in oral carcinogenesis in pediatric subjects.
... Papilloma is a benign epithelial mass which comprises fingerlike projections involving squamous epithelium. Squamous papilloma is an exophytic mass which involves soft palate, tonsils [16] or uvula. ...
... Oropharyngeal papilloma is common amongst adults [17]. Female predominance is noted with a male-to-female ratio of 1:1.5 [16]. Mean age of patients with oropharyngeal papilloma is 33 years of age [16]. ...
... Female predominance is noted with a male-to-female ratio of 1:1.5 [16]. Mean age of patients with oropharyngeal papilloma is 33 years of age [16]. The most common location is palate and tongue [18]. ...
Pharyngeal tumours are considered to be significant tumours in the head and neck region. The tumours may be either benign or malignant. These tumours can cause dysphagia and airway obstruction. The common benign lesions include vascular malformations, lingual thyroid, epidermoid cyst, pleomorphic adenoma and haemangioma. The malignant tumour is squamous cell carcinoma. Treatment of malignant pharyngeal tumour relies mainly on the tumour staging in addition to the patient’s general condition. The early-stage tumour is amenable for surgical approaches, and the late-stage tumour is treated with chemoradiation. The surgical approaches can be a transoral laser surgery and transoral robotic surgery, and these can be combined with the external approaches if neck dissection is required.
... [1,2] The findings of a study that reviewed data from 2356 biopsies of young patients (birth to 14 years) received over 15 years in an oral pathology service in Brazil revealed that papillomas were the most frequently observed benign tumors of nonodontogenic origin, corresponding to 29.5% of these lesions. [3] Al Khateeb et al., [4] in a 10-year retrospective analysis of the types and distribution of oral and maxillofacial tumors in North Jordanian children and adolescents, reported that the papilloma was the most commonly found benign epithelial tumor in this population. Das et al., after reviewing the results from 2370 biopsies of patients up to 20 years of age collected over 11 years in the biopsy service at the University of Illinois, USA, reported that the papilloma was the most prevalent oral neoplasia in this population. ...
Oral papilloma is a benign proliferation of the stratified epithelium, which results in a papillary or verrucous exophytic mass, which can be induced by human papillomavirus. These oral mucosa lesions are most often asymptomatic and have small progression. Laser-assisted surgery is common nowadays with several advantages including successful hemostasis, devoid of sutures, wound sterilization and minimal postoperative pain, and edema. The aim of this report is to present the oral papilloma in a 40-year-old female patient and its treatment with soft-tissue laser. The lesion was excised with diode laser, and the healing was uneventful in a follow-up visit after 1 month. Oral papillomas can be found in young adult patient's oral cavity, and laser dentistry can be used by dental clinicians to treat these kinds of oral lesions and should be considered as an alternative to conventional surgery.
... 6 In the case of lesions located in the uvula or in places close to it, patients usually have difficulty swallowing food, therefore surgical excision should be performed as soon as possible. 7 The aim of this article is to review the literature and present the case of a squamous papilloma of the soft palate. ...
... Devi et al., 1 mention that in a sample of 464 squamous papillomas of the oral cavity, 34.3% of these lesions were located in the palatal complex (hard palate, soft or uvula), the majority being benign and asymptomatic. 7 Benign squamous papilloma is associated with low risk types of HPV 6 and 11, 8 affecting patients of all ages, but more often diagnosed from the second to fourth decade of life, 8 which suggests that the appearance of these lesions is more frequent in people with active sexual life. However, some studies have not been able to demonstrate a correlation between the practice of oral sex and HPV infection, suggesting also that they operate non-sexual transmission mechanisms. ...
... It usually occurs in the third to fifth decades of life as an isolated small growth (<1 cm diameter) but lesion as large as 3 cm have also been reported. 4,5 The most common sites for localization of the lesions include the tongue and soft palate, but any surface of the oral cavity can be affected. The color of the lesion depends on the surface keratinization and can range from pink red to even white. ...
Soft tissue overgrowths inside oral cavity can present with wide range of clinical manifestations and some of them can be even asymptomatic. Oral squamous papilloma is one of that asymptomatic lesion described in the literature with extremely low virulence and infectivity rate. Soft tissue overgrowths can sometimes interfere with denture retention. Here we report a case of squamous papilloma in a 60 years old edentulous female who presented with loss of denture retention.
Keywords: denture retention; papilloma; sialadenoma papilliferum.
... [8][9][10] HPV types six and 11 are the most common pathogens for oral squamous papillomas, but there is controversy regarding its viral origin. [18] In the oral cavity, VC occurs on buccal mucosa, gingival and alveolar ridge. Predominantly being a squamous mucosal lesion, VC may also be found on cutaneous surfaces. ...
... [4] Intraorally, oral squamous papillomas are found most commonly on the palate (which was observed in the case reported here), lips, buccal mucosa, gingiva, and tongue but any region of the oral cavity could be impressed, such as the uvula, epiglottis, or tonsil. [16,18] These lesions generally measure less than 1 cm in the largest dimension and appear as pink to white exophytic granular or cauliflower-like surface alterations and may be pedunculated or sessile in the configuration. The lesions are generally asymptomatic, as in the present case, although Devi et al. [18] and Goodstein et al. [21] reported two cases of a squamous papilloma of the uvula that atypically produced symptoms. ...
... [16,18] These lesions generally measure less than 1 cm in the largest dimension and appear as pink to white exophytic granular or cauliflower-like surface alterations and may be pedunculated or sessile in the configuration. The lesions are generally asymptomatic, as in the present case, although Devi et al. [18] and Goodstein et al. [21] reported two cases of a squamous papilloma of the uvula that atypically produced symptoms. Squamous papillomas are divided into two forms: Isolated-solitary and multiple-recurring. ...
Verrucous carcinoma (VC) of oral cavity is a rare variant of well-differentiated squamous cell carcinoma and squamous papilloma is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. There is a certain clinical similarity between squamous cell papilloma and VC. We presented a report of two cases which are VC and squamous cell papilloma that are showed the same clinical appearance but different pathological appearance, with a review of the literature.
The range of benign and malignant entities encountered in the oropharynx is much smaller, relative to the oral cavity and there are no “precursor” lesions in the oropharynx. The biology, morphology, treatment, and staging of oropharyngeal squamous carcinomas are vastly different than squamous carcinomas just centimeters anterior, in the oral cavity. High-risk Human Papillomavirus (HR-HPV) -mediated oropharyngeal cancers can be recognized by the following possible features: nonkeratinizing, “inside-out” maturation, and multinucleated and/pr pleomorphic tumor cells. Metastatic HR-HPV mediated oropharyngeal cancers are frequently cystic. Immunohistochemistry for p16 is now standard of care for staging oropharyngeal carcinomas according to new 8th American Joint Cancer Committee standards.
The oral cavity and oropharynx play an important role in speech, swallowing, respiration, and other vital physiologic functions. Any visit to a medical professional that includes a physical examination often includes the classic instruction to open the mouth and say “ah.” Traditionally, a handheld flashlight or head mirror and/or light may provide sufficient illumination for adequate examination of these areas. However, with optical endoscopes, we may be able to visualize these areas with greater detail and educate our patients with visual images.
The present is a case of a patient with a foreign body sensation in the throat and final diagnosis of inverting papilloma and squamous papilloma of uvula. After surgery, the evolution was successful.
Epiglottic masses may be cystic, granulomatous, infectious, benign or malignant neoplastic, or manifestations of a systemic disease. When large in size, the airway may become obstructed, and when accompanied by suspicious features such as cartilaginous invasion, extension to the pre-epiglottic or para-glottic spaces, or lymphadenopathy, the radiologist must consider malignancy as a primary differential diagnosis. However, when only benign features are identified, the differential diagnosis is broad. We present a 65-year-old female with an incidental 1 cm exophytic, pedunculated, papillomatous lesion on the laryngeal surface of the epiglottis discovered upon endoscopic evaluation for dyspepsia and heartburn. Because of her risk factors for malignancy, CT scan was requested and revealed only benign features. Subsequent excisional biopsy revealed a benign squamous papilloma; however, multiple additional differential considerations were entertained preoperatively.
© The Author(s) 2015.
