Microscopic structural and cellular findings of control (A–D), 12 wk TEAR (E–H), and 12 wk ACLT (I–L) left menisci. Coronal cross- section (A, E, and I) stained with FG-Saf-O illustrate intact control menisci with even distribution of sulfated GAG through RW and WW zones, a RW zone longitudinal tear in lateral meniscus of TEAR animal, and fibrillation of articulating surface of medial meniscus of ACLT animal [scale bar 1⁄4 2 mm for A, E, and I]; synovial and meniscal junction (B, F, and J) illustrating high proliferation of cells for TEAR (F) and ACLT (J). Meniscus and synovium indicated with M and S, respectively. Articulating surfaces (C, G, and K) for both TEAR and ACLT compared to control [scale bar 1⁄4 200 m m for B, C, F, G, J, and K]; Fibrochondrocyte distribution (D, H, and L) in control menisci appears even, with noticeable cell clustering and cloning for TEAR menisci, indicated with thick arrows, and cell debris for ACLT menisci, indicated by narrow arrows [scale bar 1⁄4 100 m m for D, H, and L]. (Color version of figure is available online.) 

Contexts in source publication

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... in morphology between control, 12 wk TEAR, and ACLT menisci were observed at the micro- scopic level. Representative cross-sections of control, 12 wk TEAR, and ACLT left-limb menisci are illustrated in Fig. 3. Positive staining for sulfated GAGs appeared to be equally distributed in RW and WW zones for central regions of control animals (Fig. 3A). However, inconsistent coverage of sulfated GAGs was observed in the central regions for lateral TEAR and medial ACLT menisci (Fig. 3B, C, and D). A distinct longitudi- nal tear is observed in the ...

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... in morphology between control, 12 wk TEAR, and ACLT menisci were observed at the micro- scopic level. Representative cross-sections of control, 12 wk TEAR, and ACLT left-limb menisci are illustrated in Fig. 3. Positive staining for sulfated GAGs appeared to be equally distributed in RW and WW zones for central regions of control animals (Fig. 3A). However, inconsistent coverage of sulfated GAGs was observed in the central regions for lateral TEAR and medial ACLT menisci (Fig. 3B, C, and D). A distinct longitudi- nal tear is observed in the mid-body region of a lateral TEAR meniscus (Fig. 3E). Fibrillation of the medial ACLT menisci is also highlighted in Fig. 3I (inset), which ...

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... of control, 12 wk TEAR, and ACLT left-limb menisci are illustrated in Fig. 3. Positive staining for sulfated GAGs appeared to be equally distributed in RW and WW zones for central regions of control animals (Fig. 3A). However, inconsistent coverage of sulfated GAGs was observed in the central regions for lateral TEAR and medial ACLT menisci (Fig. 3B, C, and D). A distinct longitudi- nal tear is observed in the mid-body region of a lateral TEAR meniscus (Fig. 3E). Fibrillation of the medial ACLT menisci is also highlighted in Fig. 3I (inset), which was observed in two of the three ACLT medial menisci. Fibrillation was also observed along the supe- rior surface of lateral menisci for both 12 ...

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... GAGs appeared to be equally distributed in RW and WW zones for central regions of control animals (Fig. 3A). However, inconsistent coverage of sulfated GAGs was observed in the central regions for lateral TEAR and medial ACLT menisci (Fig. 3B, C, and D). A distinct longitudi- nal tear is observed in the mid-body region of a lateral TEAR meniscus (Fig. 3E). Fibrillation of the medial ACLT menisci is also highlighted in Fig. 3I (inset), which was observed in two of the three ACLT medial menisci. Fibrillation was also observed along the supe- rior surface of lateral menisci for both 12 wk TEAR animals. No microscopic fibrillation was observed in any control animals. Compared with healthy ...

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... of control animals (Fig. 3A). However, inconsistent coverage of sulfated GAGs was observed in the central regions for lateral TEAR and medial ACLT menisci (Fig. 3B, C, and D). A distinct longitudi- nal tear is observed in the mid-body region of a lateral TEAR meniscus (Fig. 3E). Fibrillation of the medial ACLT menisci is also highlighted in Fig. 3I (inset), which was observed in two of the three ACLT medial menisci. Fibrillation was also observed along the supe- rior surface of lateral menisci for both 12 wk TEAR animals. No microscopic fibrillation was observed in any control animals. Compared with healthy control menisci, both medial and lateral menisci for TEAR ani- mals demonstrated ...

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... menisci. Fibrillation was also observed along the supe- rior surface of lateral menisci for both 12 wk TEAR animals. No microscopic fibrillation was observed in any control animals. Compared with healthy control menisci, both medial and lateral menisci for TEAR ani- mals demonstrated a high proliferation of cells at the synovium-meniscus junction (Fig. 3F), as well as along the periphery of both menisci on deep and superior surfaces (Fig. 3 G). Cell proliferation at the synovium- meniscus junction for ACLT menisci was predomi- nantly demonstrated in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion ...

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... for both 12 wk TEAR animals. No microscopic fibrillation was observed in any control animals. Compared with healthy control menisci, both medial and lateral menisci for TEAR ani- mals demonstrated a high proliferation of cells at the synovium-meniscus junction (Fig. 3F), as well as along the periphery of both menisci on deep and superior surfaces (Fig. 3 G). Cell proliferation at the synovium- meniscus junction for ACLT menisci was predomi- nantly demonstrated in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion (Fig. 3 K). Cell clustering and chondrocyte cloning was observed in both medial and ...

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... medial and lateral menisci for TEAR ani- mals demonstrated a high proliferation of cells at the synovium-meniscus junction (Fig. 3F), as well as along the periphery of both menisci on deep and superior surfaces (Fig. 3 G). Cell proliferation at the synovium- meniscus junction for ACLT menisci was predomi- nantly demonstrated in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion (Fig. 3 K). Cell clustering and chondrocyte cloning was observed in both medial and lateral menisci for TEAR animals (Fig. 3H). Cellular debris was observed in both ACLT medial and lateral menisci (Fig. ...

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... (Fig. 3F), as well as along the periphery of both menisci on deep and superior surfaces (Fig. 3 G). Cell proliferation at the synovium- meniscus junction for ACLT menisci was predomi- nantly demonstrated in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion (Fig. 3 K). Cell clustering and chondrocyte cloning was observed in both medial and lateral menisci for TEAR animals (Fig. 3H). Cellular debris was observed in both ACLT medial and lateral menisci (Fig. ...

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... at the synovium- meniscus junction for ACLT menisci was predomi- nantly demonstrated in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion (Fig. 3 K). Cell clustering and chondrocyte cloning was observed in both medial and lateral menisci for TEAR animals (Fig. 3H). Cellular debris was observed in both ACLT medial and lateral menisci (Fig. ...

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... in medial menisci (Fig. 3 J), however, both medial and lateral menisci of ACLT ani- mals experienced superior and deep cellular prolifera- tion (Fig. 3 K). Cell clustering and chondrocyte cloning was observed in both medial and lateral menisci for TEAR animals (Fig. 3H). Cellular debris was observed in both ACLT medial and lateral menisci (Fig. ...