Microphotograph of a buccopalatal/lingual section of the 2-week experiment. (a) Maxilla. Most of the grafted MBCP+ particles were well maintained. (b) Higher magnification of (a) at the crest area. Undermining resorption on the pressure side was observed. (c) Higher magnification of (b). Extravasation of RBC was observed in the PDL space. Resorption bays, which indicate undermining resorption on the pressure side, were also observed. (d) Higher magnification of (a) at the buccal bone surface. New bone formation surrounding the grafted MBCP+ particles was observed. Grafted MBCP+ particles were bridged by newly formed bone. (e) Higher magnification of (d). Abundant osteoblasts were forming new bone. (f) Higher magnification of (a). Osteoblasts were forming a new bone island. (h) Higher magnification of (a). Grafted particles encircled by new bone were bridged with the buccal bone surface. (j) Higher magnification of (a). New bone was formed in the PDL space at the buccal tension area. New bone was formed from the bone. (l) Mandible. Most of the grafted MBCP+ particles were well maintained. (m) Higher magnification of (l) at the crest area. Grafted particles were resorbed by osteoclasts. (n) Higher magnification of (m). (o) Higher magnification of (l). (p) Higher magnification of (l). Bone and root surface resorption by osteoclasts were observed. (q) Higher magnification of (l). Undermining resorption at the buccal bone in the PDL area was observed. (r) Higher magnification of (q). Many osteoblasts filled the resorption bay. (s) Higher magnification of (l). Active new bone formation was found at the buccal bone surface in the apical area. (t) Higher magnification of (s). Many osteoblasts were forming a new bone encircling the grafted MBCP+ particles. (u) Higher magnification of (s). Osteoclastic and osteoblastic activities were both observed. (v) Higher magnification of (l). New bone islands were formed. (w) Higher magnification of (v). (x) Higher magnification of (v). Abundant osteoblasts were actively forming new bone islands. Masson’s trichrome stain. Original magnification was ×12.5 for (a) and (l); ×100 for (b), (d), (f), (h), (j), (m), (o), (q), (s), and (v), and ×400 for (c), (e), (g), (i), (k), (n), (p), (r), (t), (u), (w), and (x).

Microphotograph of a buccopalatal/lingual section of the 2-week experiment. (a) Maxilla. Most of the grafted MBCP+ particles were well maintained. (b) Higher magnification of (a) at the crest area. Undermining resorption on the pressure side was observed. (c) Higher magnification of (b). Extravasation of RBC was observed in the PDL space. Resorption bays, which indicate undermining resorption on the pressure side, were also observed. (d) Higher magnification of (a) at the buccal bone surface. New bone formation surrounding the grafted MBCP+ particles was observed. Grafted MBCP+ particles were bridged by newly formed bone. (e) Higher magnification of (d). Abundant osteoblasts were forming new bone. (f) Higher magnification of (a). Osteoblasts were forming a new bone island. (h) Higher magnification of (a). Grafted particles encircled by new bone were bridged with the buccal bone surface. (j) Higher magnification of (a). New bone was formed in the PDL space at the buccal tension area. New bone was formed from the bone. (l) Mandible. Most of the grafted MBCP+ particles were well maintained. (m) Higher magnification of (l) at the crest area. Grafted particles were resorbed by osteoclasts. (n) Higher magnification of (m). (o) Higher magnification of (l). (p) Higher magnification of (l). Bone and root surface resorption by osteoclasts were observed. (q) Higher magnification of (l). Undermining resorption at the buccal bone in the PDL area was observed. (r) Higher magnification of (q). Many osteoblasts filled the resorption bay. (s) Higher magnification of (l). Active new bone formation was found at the buccal bone surface in the apical area. (t) Higher magnification of (s). Many osteoblasts were forming a new bone encircling the grafted MBCP+ particles. (u) Higher magnification of (s). Osteoclastic and osteoblastic activities were both observed. (v) Higher magnification of (l). New bone islands were formed. (w) Higher magnification of (v). (x) Higher magnification of (v). Abundant osteoblasts were actively forming new bone islands. Masson’s trichrome stain. Original magnification was ×12.5 for (a) and (l); ×100 for (b), (d), (f), (h), (j), (m), (o), (q), (s), and (v), and ×400 for (c), (e), (g), (i), (k), (n), (p), (r), (t), (u), (w), and (x).

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Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The result...

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... The right side was treated by marsupialization and extraction without alveolar ridge grafting, 53 whereas the left side was managed by extraction and ridge preservation using HA-β-TCP as an alloplastic bone graft (Fig 2). 14,20,54,55 The team's rationale was to facilitate the mandibular left second molar's eruption into the extraction space, and enhance future OTM during space closure, enabling spontaneous third molar eruption. OTM by means of alloplastic bone grafts has been reported as not only possible, but also potentially improving the orthodontic treatment outcomes and periodontal-orthodontic stability. ...
... OTM by means of alloplastic bone grafts has been reported as not only possible, but also potentially improving the orthodontic treatment outcomes and periodontal-orthodontic stability. 55 However, while being biocompatible, 56 there is a lack of high-quality evidence regarding attempts to move teeth into HA-containing biomaterials such as HA-β-TCP, namely during the repeated bone resorption and deposition coupling process. 57 The scientific literature reports a variety of opinions and findings regarding OTM in grafted alveolar sites. ...
... 59,62 Hence the repeated bone resorption and deposition coupling process may be achieved through regenerated areas, 56 improving orthodontic treatment outcomes and periodontal-orthodontic stability. 55 Consequent to the scant literature concerning grafting materials beneficial for preplanned OTM, along with the comparative results in this unique case report, the question emerged regarding the choice of the bio bone graft material, HA-β-TCP, prior to the orthodontic procedure. This newly applied graft material provides a unique insight for general practitioners in general, as well as orthodontists, regarding the decision to use a certain bone grafting material and its influence on OTM and the final results. ...
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Preorthodontic socket preservation after tooth extraction is intended to enhance favorable dentoalveolar ridge morphology and architecture, and facilitate orthodontic tooth movement (OTM) and extraction space closure. This 13-year-old skeletal Class II case presents a unique opportunity to evaluate and compare the OTM extraction space closure by means of a split-mouth analysis in a single patient. The comprehensive orthodontic-periodontal treatment included nonsimultaneous extraction of the bilateral periodontally compromised mandibular first molars and the eruption of bilateral impacted mandibular canines. While the right post-extraction space underwent a natural healing process, the left one was grafted using 4BONE BCH (hydroxyapatite β-tricalcium phosphate [HA-β-TCP], HA 60%, and β-TCP 40%). The 3-year multidisciplinary treatment approach resulted in Class I relationships on the right side and Class II on the left side, improved facial appearance, and dento-skeletal jaw relationships. However, a 3-mm residual alveolar space remained unclosed on the grafted left-site, along with an unerupted left third molar. This split-mouth comparative analysis of the orthodontic space closure demonstrated a significant clinical difference in the outcome. Preorthodontic placement of HA-β-TCP grafting material on the left segment, proved to be an obstacle for OTM extraction space closure, hindering the establishment of good occlusion.
... 163 Furthermore, there is the assumption that after performing a flap surgery and the decortications, there is a substantial tissue memory loss. 164 A B C D In a study with five beagle dogs by Choi et al., 165 new bone formation was found at the buccal surface in an augmented corticotomy site. Another study by Araujo et al. 166 using five beagle dogs demonstrated that it was possible to move a tooth into an area of an alveolar ridge that 3 months previously had been augmented with a biomaterial. ...
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As we see more adults entering comprehensive orthodontic treatment, we must be more attuned to the implications of periodontal issues. In this updated chapter, Robert Vanarsdall, Ignacio Blasi and Antonino Secchi review periodontal issues that impact orthodontic tooth movement. They describe periodontal "high risk" factors, mucogingival considerations, and problems with ectopic as well as ankylosed teeth. A new section on alveolar decortication and augmentation grafting has been added to address the increased use of these procedures designed to develop the alveolar housing and potentially increase the speed of tooth movement. Excellent clinical examples are pictured throughout the chapter.
... • un essai contrôlé randomisé split-mouth sur le chien a montré une néoformation osseuse significative du côté vestibulaire quel que soit le matériau de comblement utilisé (os bovin déprotéinisé [Bio-Oss ® ], os cortical irradié [ICB] ou os synthétique [MBCP]). De façon intéressante, la plus grande néoformation osseuse était observée dans les cas de comblement avec de l'os synthétique [71] ; • un autre essai contrôlé randomisé split-mouth sur le chien soulignait l'intérêt de l'utilisation d'une membrane de collagène résorbable pour stabiliser le greffon durant la cicatrisation et prévenir l'apparition de déhiscences osseuses, tout en maintenant le niveau des tissus mous vestibulaires lors des mouvements de vestibulo-version [72] ; • Choi et al., en 2014 [73] , dans une étude sur cinq chiens, ont montré une néoformation osseuse après deux semaines dans un modèle de corticotomies augmentées par comblement avec matériau alloplastique. Ils montraient en outre que l'os néoformé envahissait les particules du matériau greffé de façon très notable à quatre semaines. ...
... Cependant, le peu de littérature sur l'efficacité des greffes relève surtout de cas cliniques (hormis les études sur le chien de Lee et al. [71,72] et Choi et al. [73] ). Il n'existe, de fait, que peu de preuves scientifiques et histologiques rigoureuses supportant l'efficacité réelle des greffes chez l'homme [73] : ...
... Cependant, le peu de littérature sur l'efficacité des greffes relève surtout de cas cliniques (hormis les études sur le chien de Lee et al. [71,72] et Choi et al. [73] ). Il n'existe, de fait, que peu de preuves scientifiques et histologiques rigoureuses supportant l'efficacité réelle des greffes chez l'homme [73] : ...