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Fig 2 - MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma
![Fig. 2 MiR-1468 promotes cell proliferation, cell cycle progression, colony formation and inhibits apoptosis in HCC cells in vitro. a Hep3B and MHCC-97 L cells that were transfected with corresponding miRNA vectors were subjected to qRT-PCR for miR-1468 expression. Overexpression of miR-1468 promoted cell proliferation (b, c), colony formation (d), cell cycle progression (e) and inhibited apoptosis (f) in Hep3B cells, while down-regulation of miR-1468 inhibited cell proliferation (b, c), colony formation (d), cell cycle progression (e) and promoted apoptosis (f) in MHCC-97 L cells. g Western blot analysis of cycle regulator Cyclin D1 and p21, apoptosis-related protein Bcl2/Bax expression in the presence and absence of miR-1468. n = six independent experiments. *P < 0.05, **P < 0.01](https://www.researchgate.net/publication/323584746/figure/fig2/AS:601233589018624@1520356666217/MiR-1468-promotes-cell-proliferation-cell-cycle-progression-colony-formation-and_Q320.jpg)
MiR-1468 promotes cell proliferation, cell cycle progression, colony formation and inhibits apoptosis in HCC cells in vitro. a Hep3B and MHCC-97 L cells that were transfected with corresponding miRNA vectors were subjected to qRT-PCR for miR-1468 expression. Overexpression of miR-1468 promoted cell proliferation (b, c), colony formation (d), cell cycle progression (e) and inhibited apoptosis (f) in Hep3B cells, while down-regulation of miR-1468 inhibited cell proliferation (b, c), colony formation (d), cell cycle progression (e) and promoted apoptosis (f) in MHCC-97 L cells. g Western blot analysis of cycle regulator Cyclin D1 and p21, apoptosis-related protein Bcl2/Bax expression in the presence and absence of miR-1468. n = six independent experiments. *P < 0.05, **P < 0.01
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