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![Methane and hydrogen concentrations before and after intervention by the experimenter[PPM,Md(P25,P75)]](profile/Hugo-Godoy/publication/333742738/figure/tbl1/AS:907836259315713@1593456439702/Methane-and-hydrogen-concentrations-before-and-after-intervention-by-the.png)
Methane and hydrogen concentrations before and after intervention by the experimenter[PPM,Md(P25,P75)]
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Background
Belimumab is a human IgG1l monoclonal antibody directed against BAFF, a B lymphocyte survival factor. It is indicated as adjuvant treatment in adult patients with active systemic lupus erythematosus (SLE), with positive autoantibodies and with a high degree of activity of the disease despite standard treatment.
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Background:
Belimumab was the first biological drug approved for Systemic Lupus Erythematosus (SLE). There is not a review focusing on all real-life experience with belimumab to date that could help to describe how this drug behaves in the Spanish clinical setting.
Objective:
To describe the characteristics of SLE patients treated with belimumab added to standard of care in real-clinical setting in Spain.
Methods:
We conducted a comprehensive scoping review of real-world data (RWD) according to PRISMA Scoping Reviews Checklist and the framework proposed by Arksey and O'Malley. PubMed and EMBASE were searched without language restriction and hand searches of relevant articles were examined.
Results:
We included data from 222 patients treated with belimumab for SLE included in 19 RWD studies conducted in Spain. The mean age was 40.9 years, 84.2% were female, and baseline scores SELENA-SLEDAI ranged between 5.9 and 12. Lupus nephritis basal prevalence was of 2.7%. The main reason for belimumab initiation was previous treatments lack of efficacy (69.7%) and the most common laboratory abnormalities were hypocomplementemia (40.9%), ANA + (34.2%), and anti-DNA (33.3%). The addition of belimumab to standard therapy was associated with a reduction of daily glucocorticoids intake in 1.4-11.1 mg at 6 months. Belimumab discontinuation was observed in 18.6% of patients.
Conclusion:
Our study helps to further explore the profile of SLE patients most likely to be treated with belimumab.
