- Social evolution of innate immunity evasion in a virus

Metapopulation structure selects for IFN shutdown MEFs in a 96-well format were inoculated with a limiting dilution of an approximately 1:1 mix of the WT and a NmAb-resistant Δ51 virus. Titres produced by each variant in each well were determined by the plaque assay. Left, Box plots of the WT and Δ51 titres in wells showing only one variant (pure; n = 20 for WT and n = 35 for Δ51) or a mixture of the two variants (mixed; n = 16). The lower and upper limits of the box indicate the twenty-fifth and seventy-fifth percentiles and the middle line shows the median. Whiskers show the tenth and ninetieth percentiles and outlying points are plotted individually. Middle, titres produced in each individual well. Right, overall WT and Δ51 yield in the metapopulation (sum of all wells).

Go to figure page

Reference

Social evolution of innate immunity evasion in a virus - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Metapopulation-structure-selects-for-IFN-shutdown-MEFs-in-a-96-well-format-were_fig5_331506991 [accessed 2 Jul, 2024]

Caption

Metapopulation structure selects for IFN shutdown
MEFs in a 96-well format were inoculated with a limiting dilution of an approximately 1:1 mix of the WT and a NmAb-resistant Δ51 virus. Titres produced by each variant in each well were determined by the plaque assay. Left, Box plots of the WT and Δ51 titres in wells showing only one variant (pure; n = 20 for WT and n = 35 for Δ51) or a mixture of the two variants (mixed; n = 16). The lower and upper limits of the box indicate the twenty-fifth and seventy-fifth percentiles and the middle line shows the median. Whiskers show the tenth and ninetieth percentiles and outlying points are plotted individually. Middle, titres produced in each individual well. Right, overall WT and Δ51 yield in the metapopulation (sum of all wells).

Embed code

<a href="https://www.researchgate.net/figure/Metapopulation-structure-selects-for-IFN-shutdown-MEFs-in-a-96-well-format-were_fig5_331506991"><img src="https://www.researchgate.net/publication/331506991/figure/fig5/AS:743260683247629@1554218564955/Metapopulation-structure-selects-for-IFN-shutdown-MEFs-in-a-96-well-format-were.png" alt="Metapopulation structure selects for IFN shutdown
MEFs in a 96-well format were inoculated with a limiting dilution of an approximately 1:1 mix of the WT and a NmAb-resistant Δ51 virus. Titres produced by each variant in each well were determined by the plaque assay. Left, Box plots of the WT and Δ51 titres in wells showing only one variant (pure; n = 20 for WT and n = 35 for Δ51) or a mixture of the two variants (mixed; n = 16). The lower and upper limits of the box indicate the twenty-fifth and seventy-fifth percentiles and the middle line shows the median. Whiskers show the tenth and ninetieth percentiles and outlying points are plotted individually. Middle, titres produced in each individual well. Right, overall WT and Δ51 yield in the metapopulation (sum of all wells)."/></a>