Figure 4 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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Metabolic alterations among responders and non-responders of methotrexate (MTX) treatment. (A) Principal component analysis showed obvious separation between the responders and non-responders. (B) Volcano plot indicates 5 differentially expressed lipids, including 3 upregulated and 2 downregulated targets. (C) Phosphatidylethanolamine PE (34: 4) and PE (38: 1) are downregulated in the responder group. (D) Five lipid components are highly enriched in the glycerophospholipid pathway. (Figures were generated by R with ggplot2_3.4.2, EnhancedVolcano_1.16.0. The Metabolic pathways analysis was based on MetaboAnalyst 6.0.).
Source publication
Background
Aberrant lipid metabolism alterations in skin tissue, blood, or urine have been implicated in psoriasis. Here, we examined lipid metabolites related to psoriasis and their association with the age of disease onset.
Material/Methods
Differences in lipid metabolites before and after methotrexate (MTX) treatment were evaluated. The discove...
Contexts in source publication
Context 1
... we performed differential lipid analysis in responders and non-responders. The principal component analysis showed an obvious separation between the groups ( Figure 4A). The volcano plot indicated 5 differentially expressed lipids, including 3 upregulated and 2 downregulated targets ( Figure 4B). ...
Context 2
... principal component analysis showed an obvious separation between the groups ( Figure 4A). The volcano plot indicated 5 differentially expressed lipids, including 3 upregulated and 2 downregulated targets ( Figure 4B). Age onset 40 A B C enriched in glycerophospholipids, and the same pathway was identified on MTX treatment ( Figure 4D). ...
