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Context 1
... antireflux barrier is created by a combination of the normal anatomical configuration of the esophagogastric junction (EG) and the strength and function of the lower esophageal sphincter (LES). A weak antireflux barrier causes reflux in the majority of patients (Figure 4). Gastroesophageal reflux disease most often occurs when LES pressure (measured manometrically) is low or the normal angulation of the EG junction is lost (as occurs when a hiatus hernia is present) ( Figure 5). ...
Context 2
... refers to the presence of inflammatory cells within the esophageal mucosa. Esophagitis may range in severity from microscopic changes in biopsies taken from an endoscopically normal-looking esophagus (microscopic esophagitis), to obviously inflamed-looking mucosa without erosion (nonerosive esophagitis), to frankly eroded or ulcerated mucosa (erosive esophagitis) (Figure 14). Although the presence of severe reflux symptoms increases the probability of erosive esophagitis, the correlation of symptoms and severity of esophagitis is relatively poor. ...
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Background
Chronic cough significantly impairs the quality of life. Although various studies focused on MNBI as assessed in the distal esophagus, scarce data are available on the clinical value of proximal measurements.
Aim
To investigate the role of proximal MNBI in the workup of patients with chronic cough and its ability to predict PPI response...
